PMID- 16272653
OWN - NLM
STAT- MEDLINE
DCOM- 20060522
LR  - 20230315
IS  - 0973-7693 (Electronic)
IS  - 0019-5456 (Linking)
VI  - 72
IP  - 10
DP  - 2005 Oct
TI  - Neonatal screening for glucose-6-phosphate dehydrogenase deficiency.
PG  - 835-7
AB  - OBJECTIVE: This study was carried out to detect the incidence of erythrocytic 
      Glucose-6 -Phosphate dehydrogenase (G-6-PD) deficiency, to compare the incidence 
      of hyperbilirubinemia in G-6-PD deficient neonates as compared to G-6-PD normal 
      neonates and to asses the usefulness of neonatal screening for G-6-PD deficiency. 
      METHOD: In a retrospective hospital based study 2,479 male and female neonates 
      consecutively born at Indraprastha Apollo hospital between July 1998 to June 2003 
      who were screened for G-6-PD levels were evaluated for the incidence of G-6-PD 
      deficiency. RESULTS: Incidence of G-6-PD deficiency was found to be 2.0%. 
      Incidence in males was 283% and female was 1.05%. The incidence of 
      hyperbilirubinemia was found to be 32% in G-6-PD deficient neonates which was 
      significantly higher than the incidence of hyperbilirubinemia in neonates with 
      normal G-6-PD, which was 12.3% (P< 0.001). CONCLUSION: Our data suggests that 
      neonatal screening for G-6-PD deficiency is a useful test for preventing and 
      early treatment of complications associated with it.
FAU - Pao, Mritunjay
AU  - Pao M
AD  - Division of Neonatology, Apollo Center for Advanced Pediatrics, Indraprastha 
      Apollo Hospital, New Delhi, India.
FAU - Kulkarni, Anjali
AU  - Kulkarni A
FAU - Gupta, Vidya
AU  - Gupta V
FAU - Kaul, Sushma
AU  - Kaul S
FAU - Balan, Saroja
AU  - Balan S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - India
TA  - Indian J Pediatr
JT  - Indian journal of pediatrics
JID - 0417442
RN  - EC 1.1.1.49 (Glucosephosphate Dehydrogenase)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Age Factors
MH  - Bilirubin/blood
MH  - Cohort Studies
MH  - Female
MH  - Glucosephosphate Dehydrogenase/blood
MH  - Glucosephosphate Dehydrogenase 
      Deficiency/complications/*diagnosis/epidemiology/genetics
MH  - Humans
MH  - Hyperbilirubinemia/diagnosis/epidemiology/therapy
MH  - India/epidemiology
MH  - Infant, Newborn
MH  - Male
MH  - *Neonatal Screening
MH  - Phototherapy
MH  - Point Mutation
MH  - Retrospective Studies
MH  - Sex Factors
EDAT- 2005/11/08 09:00
MHDA- 2006/05/23 09:00
CRDT- 2005/11/08 09:00
PHST- 2005/11/08 09:00 [pubmed]
PHST- 2006/05/23 09:00 [medline]
PHST- 2005/11/08 09:00 [entrez]
AID - 10.1007/BF02731109 [doi]
PST - ppublish
SO  - Indian J Pediatr. 2005 Oct;72(10):835-7. doi: 10.1007/BF02731109.