PMID- 16274455
OWN - NLM
STAT- MEDLINE
DCOM- 20060103
LR  - 20071115
IS  - 0906-6705 (Print)
IS  - 0906-6705 (Linking)
VI  - 14
IP  - 12
DP  - 2005 Dec
TI  - Comparative genomic hybridization analysis of cutaneous large B-cell lymphomas.
PG  - 883-90
AB  - The aim of the present study was to identify genetic aberrations in a series of 
      patients with cutaneous large B-cell lymphoma (LBCL) using comparative genomic 
      hybridization (CGH). Eighteen consecutive patients with primary (13 patients) 
      (PCLBCL) and secondary (five patients) (SCLBCL) cutaneous large B-cell lymphoma 
      were included in the study. Nine cases corresponded to PCLBCL leg type and four 
      cases primary cutaneous follicle centre-cell lymphoma (PCFCL). Chromosomal 
      imbalances (CIs) were detected in 14 of 18 samples (77.8%). All of nine cases 
      with PCLBCL leg type and two of four cases with PCFCL showed CIs (100% and 50%, 
      respectively). Regarding SCLBCL, in three of five cases (60%), CIs were detected. 
      The most frequently detected gains involved 2q, 5q, 3 and 7q and amplifications 
      affected 18, 12 and 13. Frequent losses were found in 17p. In PCLBCL leg type, 
      the most frequent gains involved 2q and 7q, amplifications were localized in 
      chromosomes 12, 13 and 18 and losses affected chromosomes 17p and 19. In PCFCL, 
      gains located in 3q, 4 and 7q were found. Our study seems to confirm clear-cut 
      differences between primary cutaneous LBCL and nodal diffuse LBCL, and it 
      suggests the presence of genotypic differences between cases of PCLBCL leg type 
      and cases of PCFCL.
FAU - Gimenez, Sonia
AU  - Gimenez S
AD  - Laboratori de Citogenetica i Biologia Molecular, Servei de Patologia, Hospital 
      del Mar (IMAS), Unitat de Recerca en Neoplasies Hematologiques, PRBB, Barcelona, 
      Spain.
FAU - Costa, Carlota
AU  - Costa C
FAU - Espinet, Blanca
AU  - Espinet B
FAU - Sole, Francesc
AU  - Sole F
FAU - Pujol, Ramon M
AU  - Pujol RM
FAU - Puigdecanet, Eulalia
AU  - Puigdecanet E
FAU - Garcia-Moreno, Pilar
AU  - Garcia-Moreno P
FAU - Sanchez, Julia
AU  - Sanchez J
FAU - Gallardo, Fernando
AU  - Gallardo F
FAU - Estrach, Teresa
AU  - Estrach T
FAU - Garcia-Muret, Pilar
AU  - Garcia-Muret P
FAU - Romagosa, Vicenc
AU  - Romagosa V
FAU - Serrano, Sergi
AU  - Serrano S
FAU - Servitje, Octavio
AU  - Servitje O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Exp Dermatol
JT  - Experimental dermatology
JID - 9301549
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromosome Aberrations
MH  - Female
MH  - Gene Amplification
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell/*genetics/metabolism/pathology
MH  - Lymphoma, Large B-Cell, Diffuse/*genetics/metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - *Nucleic Acid Hybridization
MH  - Skin Neoplasms/*genetics/metabolism/pathology
EDAT- 2005/11/09 09:00
MHDA- 2006/01/04 09:00
CRDT- 2005/11/09 09:00
PHST- 2005/11/09 09:00 [pubmed]
PHST- 2006/01/04 09:00 [medline]
PHST- 2005/11/09 09:00 [entrez]
AID - EXD376 [pii]
AID - 10.1111/j.1600-0625.2005.00376.x [doi]
PST - ppublish
SO  - Exp Dermatol. 2005 Dec;14(12):883-90. doi: 10.1111/j.1600-0625.2005.00376.x.