PMID- 16274709
OWN - NLM
STAT- MEDLINE
DCOM- 20060309
LR  - 20191210
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 87
IP  - 1
DP  - 2006 Jan 30
TI  - Involvement of GABA(B) receptors of the dorsal hippocampus on the acquisition and 
      expression of morphine-induced place preference in rats.
PG  - 31-8
AB  - In the present study, effects of intra-hippocampal CA1 (intra-CA1) injections of 
      GABA(B) receptor agonist and antagonist on the acquisition and expression of 
      morphine-induced place preference in male Wistar rats have been investigated. 
      Subcutaneous administration of different doses of morphine sulphate (0.5-6 mg/kg) 
      produced a dose-dependent conditioned place preference (CPP). Using a 3-day 
      schedule of conditioning, it was found that the GABA(B) receptor agonist, 
      baclofen (0.5-2 microg/rat; intra-CA1), or the GABA(B) receptor antagonist, 
      phaclofen (1-3 microg/rat; intra-CA1), did not produce a significant place 
      preference or place aversion. Intra-CA1 administration of baclofen (1 and 2 
      microg/rat; intra-CA1) decreased the acquisition of CPP induced by morphine (3 
      mg/kg; s.c.). On the other hand, intra-CA1 injection of phaclofen (1 and 2 
      microg/rat; intra-CA1) in combination with a lower dose of morphine (1 mg/kg) 
      elicited a significant CPP. The response of baclofen (2 microg/rat; intra-CA1) 
      was reversed by phaclofen (4 and 6 microg/rat; intra-CA1). Furthermore, intra-CA1 
      administration of baclofen but not phaclofen before testing significantly 
      decreased the expression of morphine (3 mg/kg; s.c.)-induced place preference. 
      Baclofen or phaclofen injections had no effects on locomotor activity on the 
      testing sessions. It is concluded that the GABA(B) receptors in dorsal 
      hippocampus may play an active role in morphine reward.
FAU - Zarrindast, Mohammad-Reza
AU  - Zarrindast MR
AD  - Department of Pharmacology and Iranian National Center for Addiction Studies, 
      Tehran University of Medical Sciences, Tehran, Iran. zarinmr@ams.ac.ir
FAU - Massoudi, Roohollah
AU  - Massoudi R
FAU - Sepehri, Houri
AU  - Sepehri H
FAU - Rezayof, Ameneh
AU  - Rezayof A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20051107
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (GABA-B Receptor Agonists)
RN  - 0 (GABA-B Receptor Antagonists)
RN  - 0 (Narcotics)
RN  - 0 (Receptors, GABA-B)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Animals
MH  - Association Learning/drug effects/*physiology
MH  - Conditioning, Classical/drug effects/physiology
MH  - Dose-Response Relationship, Drug
MH  - GABA-B Receptor Agonists
MH  - GABA-B Receptor Antagonists
MH  - Hippocampus/cytology/drug effects/*metabolism
MH  - Male
MH  - Morphine/*pharmacology
MH  - Narcotics/*pharmacology
MH  - Neurons/drug effects/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, GABA-B/*metabolism
MH  - *Reinforcement, Psychology
EDAT- 2005/11/09 09:00
MHDA- 2006/03/10 09:00
CRDT- 2005/11/09 09:00
PHST- 2005/05/18 00:00 [received]
PHST- 2005/08/06 00:00 [revised]
PHST- 2005/08/16 00:00 [accepted]
PHST- 2005/11/09 09:00 [pubmed]
PHST- 2006/03/10 09:00 [medline]
PHST- 2005/11/09 09:00 [entrez]
AID - S0031-9384(05)00351-3 [pii]
AID - 10.1016/j.physbeh.2005.08.041 [doi]
PST - ppublish
SO  - Physiol Behav. 2006 Jan 30;87(1):31-8. doi: 10.1016/j.physbeh.2005.08.041. Epub 
      2005 Nov 7.