PMID- 16274838 OWN - NLM STAT- MEDLINE DCOM- 20060201 LR - 20191210 IS - 0169-2607 (Print) IS - 0169-2607 (Linking) VI - 80 IP - 3 DP - 2005 Dec TI - A modified OSEM algorithm for PET reconstruction using wavelet processing. PG - 236-45 AB - Ordered subset expectation-maximization (OSEM) method in positron emission tomography (PET) has been very popular recently. It is an iterative algorithm and provides images with superior noise characteristics compared to conventional filtered backprojection (FBP) algorithms. Due to the lack of smoothness in images in OSEM iterations, however, some type of inter-smoothing is required. For this purpose, the smoothing based on the convolution with the Gaussian kernel has been used in clinical PET practices. In this paper, we incorporated a robust wavelet de-noising method into OSEM iterations as an inter-smoothing tool. The proposed wavelet method is based on a hybrid use of the standard wavelet shrinkage and the robust wavelet shrinkage to have edge preserving and robust de-noising simultaneously. The performances of the proposed method were compared with those of the smoothing methods based on the convolution with Gaussian kernel using software phantoms, physical phantoms, and human PET studies. The results demonstrated that the proposed wavelet method provided better spatial resolution characteristic than the smoothing methods based on the Gaussian convolution, while having comparable performance in noise removal. FAU - Lee, Nam-Yong AU - Lee NY AD - School of Computer Aided Science, Inje University, Korea. FAU - Choi, Yong AU - Choi Y LA - eng PT - Evaluation Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20051107 PL - Ireland TA - Comput Methods Programs Biomed JT - Computer methods and programs in biomedicine JID - 8506513 SB - IM MH - *Algorithms MH - *Artifacts MH - Image Enhancement/*methods MH - Image Interpretation, Computer-Assisted/*methods MH - Likelihood Functions MH - Models, Biological MH - Models, Statistical MH - Positron-Emission Tomography/*methods MH - Reproducibility of Results MH - Sensitivity and Specificity MH - Signal Processing, Computer-Assisted EDAT- 2005/11/09 09:00 MHDA- 2006/02/02 09:00 CRDT- 2005/11/09 09:00 PHST- 2004/04/22 00:00 [received] PHST- 2005/08/26 00:00 [revised] PHST- 2005/09/23 00:00 [accepted] PHST- 2005/11/09 09:00 [pubmed] PHST- 2006/02/02 09:00 [medline] PHST- 2005/11/09 09:00 [entrez] AID - S0169-2607(05)00193-8 [pii] AID - 10.1016/j.cmpb.2005.09.004 [doi] PST - ppublish SO - Comput Methods Programs Biomed. 2005 Dec;80(3):236-45. doi: 10.1016/j.cmpb.2005.09.004. Epub 2005 Nov 7.