PMID- 16276093
OWN - NLM
STAT- MEDLINE
DCOM- 20060203
LR  - 20071114
IS  - 1424-859X (Electronic)
IS  - 1424-8581 (Linking)
VI  - 112
IP  - 1-2
DP  - 2006
TI  - Trisomy of chromosome 18 in the baboon (Papio hamadryas anubis).
PG  - 76-81
AB  - Trisomy 18 is usually a lethal chromosomal abnormality and is the second most 
      common autosomal trisomy in humans, with an incidence of 1:8000 live births. It 
      is commonly associated with abnormalities of the lower and upper extremities, 
      having the frequency of 95% and 65%, respectively. A newborn female olive baboon 
      (Papio hamadryas anubis) was diagnosed with intrauterine growth retardation and 
      severe arthrogryposis-like congenital joint deformities. Cytogenetic analysis 
      including G-banding and fluorescence in situ hybridization (FISH) revealed that 
      the congenital abnormalities were associated with chromosomal mosaicism for 
      trisomy 18. Genetic analysis with microsatellites from chromosome 18 confirmed 
      the maternal origin of the extra chromosome 18. This is the first report of 
      trisomy 18 in the baboon, which may be a promising animal model of human disease.
CI  - Copyright 2006 S. Karger AG, Basel.
FAU - Howell, K H
AU  - Howell KH
AD  - Cornell University, Ithaca, NY, USA.
FAU - Hubbard, G B
AU  - Hubbard GB
FAU - Moore, C M
AU  - Moore CM
FAU - Dunn, B G
AU  - Dunn BG
FAU - von Kap-Herr, C
AU  - von Kap-Herr C
FAU - Raveendran, M
AU  - Raveendran M
FAU - Rogers, J A
AU  - Rogers JA
FAU - Leland, M M
AU  - Leland MM
FAU - Brasky, K M
AU  - Brasky KM
FAU - Nathanielsz, P W
AU  - Nathanielsz PW
FAU - Schlabritz-Loutsevitch, N E
AU  - Schlabritz-Loutsevitch NE
LA  - eng
GR  - P51 RR013986/RR/NCRR NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Cytogenet Genome Res
JT  - Cytogenetic and genome research
JID - 101142708
SB  - IM
MH  - Abnormalities, Multiple/genetics/*veterinary
MH  - Animals
MH  - Animals, Newborn
MH  - Chromosome Aberrations
MH  - Chromosome Mapping
MH  - Chromosomes, Human
MH  - Chromosomes, Mammalian
MH  - Female
MH  - Humans
MH  - Male
MH  - Monkey Diseases/*genetics
MH  - Papio hamadryas/*genetics
MH  - Pedigree
MH  - *Trisomy
EDAT- 2005/11/09 09:00
MHDA- 2006/02/04 09:00
CRDT- 2005/11/09 09:00
PHST- 2005/01/14 00:00 [received]
PHST- 2005/03/01 00:00 [accepted]
PHST- 2005/11/09 09:00 [pubmed]
PHST- 2006/02/04 09:00 [medline]
PHST- 2005/11/09 09:00 [entrez]
AID - 87516 [pii]
AID - 10.1159/000087516 [doi]
PST - ppublish
SO  - Cytogenet Genome Res. 2006;112(1-2):76-81. doi: 10.1159/000087516.