PMID- 16277670
OWN - NLM
STAT- MEDLINE
DCOM- 20060110
LR  - 20181113
IS  - 1478-6362 (Electronic)
IS  - 1478-6354 (Print)
IS  - 1478-6354 (Linking)
VI  - 7
IP  - 6
DP  - 2005
TI  - A functional variant of Fcgamma receptor IIIA is associated with rheumatoid 
      arthritis in individuals who are positive for anti-glucose-6-phosphate isomerase 
      antibodies.
PG  - R1183-8
AB  - Anti-glucose-6-phosphate isomerase (GPI) antibodies are known to be arthritogenic 
      autoantibodies in K/BxN mice, although some groups have reported that few healthy 
      humans retain these antibodies. The expression of Fcgamma receptors (FcgammaRs) 
      is genetically regulated and has strong implications for the development of 
      experimental arthritis. The interaction between immune complexes and FcgammaRs 
      might therefore be involved in the pathogenesis of some arthritic conditions. To 
      explore the relationship between functional polymorphisms in FcgammaRs 
      (FCGR3A-158V/F and FCGR2A-131H/R) and arthritis in individuals positive for 
      anti-GPI antibodies, we evaluated these individuals with respect to FCGR 
      genotype. Genotyping for FCGR3A-158V/F and FCGR2A-131H/R was performed by PCR 
      amplification of the polymorphic site, followed by site specific restriction 
      digestion using the genome of 187 Japanese patients with rheumatoid arthritis 
      (including 23 who were anti-GPI antibody positive) and 158 Japanese healthy 
      individuals (including nine who were anti-GPI antibody positive). We report here 
      on the association of FCGR3A-158V/F functional polymorphism with anti-GPI 
      antibody positive status. Eight out of nine healthy individuals who were positive 
      for anti-GPI antibodies possessed the homozygous, low affinity genotype 
      FCGR3A-158F (odds ratio = 0.09, 95% confidence interval 0.01-0.89; P = 0.0199), 
      and probably were 'protected' from arthritogenic antibodies. Moreover, among 
      those who were homozygous for the high affinity genotype FCGR3A-158V/V, there 
      were clear differences in anti-human and anti-rabbit GPI titres between patients 
      with rheumatoid arthritis and healthy subjects (P = 0.0027 and P = 0.0015, 
      respectively). Our findings provide a molecular model of the genetic regulation 
      of autoantibody-induced arthritis by allele-specific affinity of the FcgammaRs.
FAU - Matsumoto, Isao
AU  - Matsumoto I
AD  - Clinical Immunology, University of Tsukuba, Ibaraki, Japan. 
      ismatsu@md.tsukuba.ac.jp
FAU - Zhang, Hua
AU  - Zhang H
FAU - Muraki, Yoshifumi
AU  - Muraki Y
FAU - Hayashi, Taichi
AU  - Hayashi T
FAU - Yasukochi, Takanori
AU  - Yasukochi T
FAU - Kori, Yuko
AU  - Kori Y
FAU - Goto, Daisuke
AU  - Goto D
FAU - Ito, Satoshi
AU  - Ito S
FAU - Tsutsumi, Akito
AU  - Tsutsumi A
FAU - Sumida, Takayuki
AU  - Sumida T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050811
PL  - England
TA  - Arthritis Res Ther
JT  - Arthritis research & therapy
JID - 101154438
RN  - 0 (Antigens, CD)
RN  - 0 (Autoantibodies)
RN  - 0 (FCGR3B protein, human)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (Receptors, IgG)
RN  - EC 5.3.1.9 (Glucose-6-Phosphate Isomerase)
SB  - IM
MH  - Adult
MH  - Antigens, CD/*genetics
MH  - Arthritis, Rheumatoid/genetics/*immunology
MH  - Autoantibodies/*immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - GPI-Linked Proteins
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Glucose-6-Phosphate Isomerase/*immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*immunology
MH  - Receptors, IgG/*genetics
PMC - PMC1297563
EDAT- 2005/11/10 09:00
MHDA- 2006/01/13 09:00
PMCR- 2005/08/11
CRDT- 2005/11/10 09:00
PHST- 2005/02/04 00:00 [received]
PHST- 2005/07/04 00:00 [revised]
PHST- 2005/07/19 00:00 [accepted]
PHST- 2005/11/10 09:00 [pubmed]
PHST- 2006/01/13 09:00 [medline]
PHST- 2005/11/10 09:00 [entrez]
PHST- 2005/08/11 00:00 [pmc-release]
AID - ar1802 [pii]
AID - 10.1186/ar1802 [doi]
PST - ppublish
SO  - Arthritis Res Ther. 2005;7(6):R1183-8. doi: 10.1186/ar1802. Epub 2005 Aug 11.