PMID- 16278098
OWN - NLM
STAT- MEDLINE
DCOM- 20060321
LR  - 20181203
IS  - 1525-5050 (Print)
IS  - 1525-5050 (Linking)
VI  - 8
IP  - 1
DP  - 2006 Feb
TI  - Nonconvulsive status epilepticus due to cefepime in a patient with normal renal 
      function.
PG  - 312-4
AB  - Status epilepticus and encephalopathy have been reported with use of 
      cephalosporins in patients with renal failure. We here report the case of a 
      79-year-old patient with normal renal function who developed subtle mental status 
      changes during cefepime therapy for urinary tract infection. Emergent 
      electroencephalography revealed evidence of nonconvulsive status epilepticus 
      (NCSE), which responded initially to lorazepam. Later, the patient's NCSE 
      gradually resolved only after cefepime was discontinued, with mental status 
      returning to baseline as the electroencephalography changes resolved. It should 
      be recognized that cefepime therapy can cause NCSE even in the presence of normal 
      renal function. Measurement of serum concentrations and changes in dosing 
      guidelines can probably prevent NCSE during cefepime therapy.
FAU - Maganti, Rama
AU  - Maganti R
AD  - Marshfield Clinic--Wausau Center, Wausau, WI, USA. 
      maganti.rama@marshfieldclinic.org
FAU - Jolin, David
AU  - Jolin D
FAU - Rishi, Daljeet
AU  - Rishi D
FAU - Biswas, Amit
AU  - Biswas A
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20051108
PL  - United States
TA  - Epilepsy Behav
JT  - Epilepsy & behavior : E&B
JID - 100892858
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anticonvulsants)
RN  - 0 (Cephalosporins)
RN  - 807PW4VQE3 (Cefepime)
RN  - O26FZP769L (Lorazepam)
SB  - IM
MH  - Aged
MH  - Anti-Bacterial Agents/*adverse effects/therapeutic use
MH  - Anticonvulsants/*therapeutic use
MH  - Cefepime
MH  - Cephalosporins/*adverse effects/therapeutic use
MH  - Electroencephalography
MH  - Female
MH  - Humans
MH  - Lorazepam/*therapeutic use
MH  - Status Epilepticus/*chemically induced/drug therapy
MH  - Urinary Tract Infections/drug therapy
EDAT- 2005/11/10 09:00
MHDA- 2006/03/22 09:00
CRDT- 2005/11/10 09:00
PHST- 2005/08/02 00:00 [received]
PHST- 2005/09/13 00:00 [revised]
PHST- 2005/09/19 00:00 [accepted]
PHST- 2005/11/10 09:00 [pubmed]
PHST- 2006/03/22 09:00 [medline]
PHST- 2005/11/10 09:00 [entrez]
AID - S1525-5050(05)00365-3 [pii]
AID - 10.1016/j.yebeh.2005.09.010 [doi]
PST - ppublish
SO  - Epilepsy Behav. 2006 Feb;8(1):312-4. doi: 10.1016/j.yebeh.2005.09.010. Epub 2005 
      Nov 8.