PMID- 16278245
OWN - NLM
STAT- MEDLINE
DCOM- 20060502
LR  - 20131121
IS  - 0193-1849 (Print)
IS  - 0193-1849 (Linking)
VI  - 290
IP  - 4
DP  - 2006 Apr
TI  - Metabolic response to carbohydrate ingestion during exercise in males and 
      females.
PG  - E708-15
AB  - The present study investigated potential sex-related differences in the metabolic 
      response to carbohydrate (CHO) ingestion during exercise. Moderately 
      endurance-trained men and women (n = 8 for each sex) performed 2 h of cycling at 
      approximately 67% Vo(2 max) with water (WAT) or CHO ingestion (1.5 g of 
      glucose/min). Substrate oxidation and kinetics were quantified during exercise 
      using indirect calorimetry and stable isotope techniques ([(13)C]glucose 
      ingestion, [6,6-(2)H(2)]glucose, and [(2)H(5)]glycerol infusion). In both sexes, 
      CHO ingestion significantly increased the rates of appearance (R(a)) and 
      disappearance (R(d)) of glucose during exercise compared with WAT ingestion 
      [males: WAT, approximately 28-29 micromol x kg lean body mass (LBM)(-1) x 
      min(-1); CHO, approximately 53 micromol x kg LBM(-1) x min(-1); females: WAT, 
      approximately 28-29 micromol x kg LBM(-1) x min(-1); CHO, approximately 61 
      micromol x kg LBM(-1) x min(-1); main effect of trial, P < 0.05]. The 
      contribution of plasma glucose oxidation to the energy yield was significantly 
      increased with CHO ingestion in both sexes (from approximately 10% to 
      approximately 20% of energy expenditure; main effect of trial, P < 0.05). 
      Liver-derived glucose oxidation was reduced, although the rate of muscle glycogen 
      oxidation was unaffected with CHO ingestion (males: WAT, 108 +/- 12 micromol x kg 
      LBM(-1) x min(-1); CHO, 108 +/- 11 micromol x kg LBM(-1) x min(-1); females: WAT, 
      89 +/- 10 micromol x kg LBM(-1) x min(-1); CHO, 93 +/- 11 micromol x kg LBM(-1) x 
      min(-1)). CHO ingestion reduced fat oxidation and lipolytic rate (R(a) glycerol) 
      to a similar extent in both sexes. Finally, ingested CHO was oxidized at similar 
      rates in men and women during exercise (peak rates of 0.70 +/- 0.08 and 0.65 +/- 
      0.06 g/min, respectively). The present investigation suggests that the metabolic 
      response to CHO ingestion during exercise is largely similar in men and women.
FAU - Wallis, Gareth A
AU  - Wallis GA
AD  - School of Sport and Exercise Sciences, University of Birmingham, UK.
FAU - Dawson, Ruth
AU  - Dawson R
FAU - Achten, Juul
AU  - Achten J
FAU - Webber, Jonathan
AU  - Webber J
FAU - Jeukendrup, Asker E
AU  - Jeukendrup AE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051108
PL  - United States
TA  - Am J Physiol Endocrinol Metab
JT  - American journal of physiology. Endocrinology and metabolism
JID - 100901226
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
RN  - 33X04XA5AT (Lactic Acid)
RN  - IY9XDZ35W2 (Glucose)
RN  - PDC6A3C0OX (Glycerol)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Calorimetry, Indirect
MH  - Dietary Carbohydrates/*administration & dosage/metabolism
MH  - Exercise/*physiology
MH  - Fatty Acids, Nonesterified/blood
MH  - Female
MH  - Glucose/metabolism
MH  - Glycerol/blood
MH  - Humans
MH  - Insulin/blood
MH  - Lactic Acid/blood
MH  - Male
MH  - Sex Factors
EDAT- 2005/11/10 09:00
MHDA- 2006/05/04 09:00
CRDT- 2005/11/10 09:00
PHST- 2005/11/10 09:00 [pubmed]
PHST- 2006/05/04 09:00 [medline]
PHST- 2005/11/10 09:00 [entrez]
AID - 00357.2005 [pii]
AID - 10.1152/ajpendo.00357.2005 [doi]
PST - ppublish
SO  - Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E708-15. doi: 
      10.1152/ajpendo.00357.2005. Epub 2005 Nov 8.