PMID- 16280075
OWN - NLM
STAT- MEDLINE
DCOM- 20060313
LR  - 20221020
IS  - 1476-069X (Electronic)
IS  - 1476-069X (Linking)
VI  - 4
DP  - 2005 Nov 9
TI  - Fertility in four regions spanning large contrasts in serum levels of widespread 
      persistent organochlorines: a cross-sectional study.
PG  - 26
AB  - BACKGROUND: Persistent organochlorine pollutants (POPs) may interfere with 
      reproductive function but direct evidence in humans is very limited. METHODS: 
      Fertility was examined in four regions with contrasting blood levels of POPs. 
      Pregnant women and their partners in Warsaw (Poland), Kharkiv (Ukraine) and 
      Greenland were consecutively enrolled during antenatal visits. Swedish fishermen 
      and their spouses were recruited separately and independently of current 
      pregnancy. Lipid adjusted serum concentrations of 
      2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis 
      (p-chlorophenyl)-ethylene (DDE) were available for both partners. Time to 
      pregnancy interviews were obtained among 2269 women and 798 men provided a semen 
      sample. RESULTS: Inuits had high levels of both POP markers, Swedish fishermen 
      were high in CB-153 but low in DDE, men from Kharkiv were high in DDE and low in 
      CB-153 while men from Warsaw were low in CB-153 and had intermediate DDE levels. 
      Compared to Warsaw couples, fecundability was reduced among couples from Kharkiv 
      [adjusted fecundability ratio (FR) 0.64 (95% CI 0.5-0.8)] and elevated in Swedish 
      fishermen families [FR 1.26 (95% CI 1.0-1.6)]. Adjusted geometric means of sperm 
      counts and morphology did not differ between regions while sperm motility was 
      higher in men living in Warsaw. CONCLUSION: We observed regional differences in 
      time to pregnancy and sperm motility that may be related to regional differences 
      in POP blood levels, but other interpretations are also plausible. In particular, 
      differences in access to safe contraception and in the prevalence of 
      contraceptive failures are most likely to bias comparisons of time to pregnancy.
FAU - Toft, Gunnar
AU  - Toft G
AD  - Department of Occupational Medicine, Aarhus University Hospital, Noerrebrogade 
      44, build, 2C, DK-8000 Aarhus C, Denmark. gutof@as.aaa.dk
FAU - Axmon, Anna
AU  - Axmon A
FAU - Giwercman, Aleksander
AU  - Giwercman A
FAU - Thulstrup, Ane Marie
AU  - Thulstrup AM
FAU - Rignell-Hydbom, Anna
AU  - Rignell-Hydbom A
FAU - Pedersen, Henning Sloth
AU  - Pedersen HS
FAU - Ludwicki, Jan K
AU  - Ludwicki JK
FAU - Zvyezday, Valentina
AU  - Zvyezday V
FAU - Zinchuk, Andery
AU  - Zinchuk A
FAU - Spano, Marcello
AU  - Spano M
FAU - Manicardi, Gian Carlo
AU  - Manicardi GC
FAU - Bonefeld-Jorgensen, Eva C
AU  - Bonefeld-Jorgensen EC
FAU - Hagmar, Lars
AU  - Hagmar L
FAU - Bonde, Jens Peter
AU  - Bonde JP
CN  - INUENDO
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051109
PL  - England
TA  - Environ Health
JT  - Environmental health : a global access science source
JID - 101147645
RN  - 0 (Biomarkers)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
SB  - IM
MH  - Biomarkers/blood
MH  - Cross-Sectional Studies
MH  - Environmental Exposure/adverse effects/*analysis
MH  - Environmental Pollutants/*adverse effects/blood
MH  - Female
MH  - Fertility/*drug effects
MH  - Gas Chromatography-Mass Spectrometry
MH  - Greenland
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood/*toxicity
MH  - Male
MH  - Poland
MH  - Pregnancy
MH  - Prenatal Care
MH  - Semen/*drug effects
MH  - Sperm Count
MH  - Spouses
MH  - Sweden
MH  - Ukraine
PMC - PMC1308837
EDAT- 2005/11/11 09:00
MHDA- 2006/03/15 09:00
PMCR- 2005/11/09
CRDT- 2005/11/11 09:00
PHST- 2005/08/11 00:00 [received]
PHST- 2005/11/09 00:00 [accepted]
PHST- 2005/11/11 09:00 [pubmed]
PHST- 2006/03/15 09:00 [medline]
PHST- 2005/11/11 09:00 [entrez]
PHST- 2005/11/09 00:00 [pmc-release]
AID - 1476-069X-4-26 [pii]
AID - 10.1186/1476-069X-4-26 [doi]
PST - epublish
SO  - Environ Health. 2005 Nov 9;4:26. doi: 10.1186/1476-069X-4-26.