PMID- 16280356
OWN - NLM
STAT- MEDLINE
DCOM- 20060621
LR  - 20220317
IS  - 1355-4786 (Print)
IS  - 1355-4786 (Linking)
VI  - 12
IP  - 3
DP  - 2006 May-Jun
TI  - HLA-G in human reproduction: aspects of genetics, function and pregnancy 
      complications.
PG  - 209-32
AB  - The non-classical human leukocyte antigen (HLA) class Ib genes, HLA-E, -G and -F, 
      are located on chromosome 6 in the human major histocompatibility complex (MHC). 
      HLA class Ib antigens resemble the HLA class Ia antigens in many ways, but 
      several major differences have been described. This review will, in particular, 
      discuss HLA-G and its role in human reproduction and in the human MHC. HLA-G 
      seems to be important in the modulation of the maternal immune system during 
      pregnancy and thereby the maternal acceptance of the semiallogenic fetus. Recent 
      findings regarding aspects of HLA-G polymorphism, the possible significance of 
      this polymorphism in respect to HLA-G function and certain complications of 
      pregnancy (such as pre-eclampsia and recurrent spontaneous abortions (RSA)) are 
      discussed together with possible importance to IVF. Finally, aspects of a 
      possible role of HLA-G in organ transplantation and in inflammatory or autoimmune 
      disease, and of HLA-G in an evolutionary context, are also briefly examined.
FAU - Hviid, Thomas Vauvert F
AU  - Hviid TV
AD  - Department of Clinical Biochemistry, Copenhagen University Hospital, 
      Rigshospitalet. hviid@dadlnet.dk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20051109
PL  - England
TA  - Hum Reprod Update
JT  - Human reproduction update
JID - 9507614
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Female
MH  - Fertilization in Vitro
MH  - Genes, MHC Class I
MH  - HLA Antigens/*genetics/*immunology
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*genetics/*immunology
MH  - Humans
MH  - *Polymorphism, Genetic
MH  - Pregnancy
MH  - Pregnancy Complications/*immunology
MH  - Reproduction/*immunology
RF  - 201
EDAT- 2005/11/11 09:00
MHDA- 2006/06/22 09:00
CRDT- 2005/11/11 09:00
PHST- 2005/11/11 09:00 [pubmed]
PHST- 2006/06/22 09:00 [medline]
PHST- 2005/11/11 09:00 [entrez]
AID - dmi048 [pii]
AID - 10.1093/humupd/dmi048 [doi]
PST - ppublish
SO  - Hum Reprod Update. 2006 May-Jun;12(3):209-32. doi: 10.1093/humupd/dmi048. Epub 
      2005 Nov 9.