PMID- 16280979
OWN - NLM
STAT- MEDLINE
DCOM- 20060413
LR  - 20061115
IS  - 1090-0535 (Electronic)
IS  - 1090-0535 (Linking)
VI  - 11
DP  - 2005 Nov 1
TI  - Role of the CCL2/MCP-1 -2518A>G gene polymorphism in HLA-B27 associated uveitis.
PG  - 896-900
AB  - PURPOSE: Acute anterior uveitis (AAU) is the most common form of uveitis. Up to 
      50% of patients with AAU are HLA-B27 positive. Since HLA B27 itself plays only a 
      minor role in the overall genetic background, other genetic variants are likely 
      to contribute to the susceptibility to AAU. The chemokine (C-C motif) ligand 2 
      (CCL2) gene, coding for monocyte chemoattractant protein-1 (MCP-1), a chemotactic 
      cytokine, is involved in the induction of uveitis. A CCL2 gene polymorphism, 
      which is characterized by an A>G substitution at nucleotide -2518 in the promoter 
      region of CCL2 has been previously shown to affect MCP-1 synthesis. The purpose 
      of the present study was to investigate a hypothesized association between this 
      genetic variant and the presence of HLA-B27 associated AAU. METHODS: The study 
      group comprised 114 patients with HLA-B27 associated AAU. One hundred and eleven 
      healthy HLA-B27 positive individuals served as the HLA-B27 positive control 
      group, whereas 81 healthy HLA-B27 negative individuals served as a HLA-B27 
      negative control group. Genotyping for the CCL2 -2518A>G polymorphism was 
      performed by polymerase chain reaction. RESULTS: Carriers of a CCL2 -2518G allele 
      were found significantly more often in patients with HLA-B27 associated AAU than 
      among HLA-B27 positive controls (49.2% and 31.5%, respectively; odds ratio 2.1; 
      95% confidence interval 1.2-3.6; p=0.007). CONCLUSIONS: Our data suggest that the 
      CCL2 -2518A>G polymorphism may play a role in HLA-B27 associated acute anterior 
      uveitis.
FAU - Wegscheider, Beate Julia
AU  - Wegscheider BJ
AD  - Department of Ophthalmology, Medical University Graz, Graz, Austria.
FAU - Weger, Martin
AU  - Weger M
FAU - Renner, Wilfried
AU  - Renner W
FAU - Posch, Ursula
AU  - Posch U
FAU - Ulrich, Silvia
AU  - Ulrich S
FAU - Hermann, Josef
AU  - Hermann J
FAU - Ardjomand, Navid
AU  - Ardjomand N
FAU - Haller-Schober, Eva-Maria
AU  - Haller-Schober EM
FAU - El-Shabrawi, Yosuf
AU  - El-Shabrawi Y
LA  - eng
PT  - Journal Article
DEP - 20051101
PL  - United States
TA  - Mol Vis
JT  - Molecular vision
JID - 9605351
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - Female
MH  - Genotype
MH  - HLA-B27 Antigen/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide/*physiology
MH  - Retrospective Studies
MH  - Uveitis, Anterior/*genetics
EDAT- 2005/11/11 09:00
MHDA- 2006/04/14 09:00
CRDT- 2005/11/11 09:00
PHST- 2005/11/11 09:00 [pubmed]
PHST- 2006/04/14 09:00 [medline]
PHST- 2005/11/11 09:00 [entrez]
AID - v11/a106 [pii]
PST - epublish
SO  - Mol Vis. 2005 Nov 1;11:896-900.