PMID- 16282347
OWN - NLM
STAT- MEDLINE
DCOM- 20060403
LR  - 20210206
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 107
IP  - 5
DP  - 2006 Mar 1
TI  - Human leukocyte antigen (HLA) DR15 is associated with reduced incidence of acute 
      GVHD in HLA-matched allogeneic transplantation but does not impact chronic GVHD 
      incidence.
PG  - 1970-3
AB  - The DR15 allele at the HLA DRB1 locus is a marker for immune-mediated bone marrow 
      failure syndromes. We hypothesized that HLA DR15 plays a role in T-cell 
      interactions with hematopoiesis and investigated the role of HLA DR15 on 
      graft-versus-host disease (GVHD) and graft-versus-leukemia effects in HLA-matched 
      allogeneic blood or marrow transplantation (BMT) performed for myeloid 
      malignancies. We performed a retrospective analysis of 119 consecutive related 
      and 48 consecutive unrelated allogeneic BMT for myeloid malignancies treated 
      between 1991 and 2005 to investigate the influence of HLA DR15 on overall 
      survival (OS), progression-free survival (PFS), and incidence of grades II to IV 
      acute GVHD. HLA DR15 was determined by either molecular (n = 108) or serologic (n 
      = 59) methods. The incidence of HLA DR15 was similar to the general white 
      population (35/167 = 21%). There were no significant differences in 
      transplantation characteristics between the HLA DR15-positive and -negative 
      groups. There was no significant difference in chronic GVHD, OS, or PFS between 
      the HLA DR15-positive versus-negative groups in any disease or donor relation 
      subgroups. The HLA DR15-positive group experienced a significantly lower 
      incidence of acute GVHD grades II to IV: 23% versus 42% (P = .041). These results 
      suggest that HLA DR15 reduces the risk of acute GVHD.
FAU - Battiwalla, Minoo
AU  - Battiwalla M
AD  - Department of Medicine and Laboratory Medicine, Blood and Marrow Transplantation, 
      Roswell Park Cancer Institute, Buffalo, NY 14202, USA. 
      minoo.battiwalla@roswellpark.org
FAU - Hahn, Theresa
AU  - Hahn T
FAU - Radovic, Marija
AU  - Radovic M
FAU - Roy, Hilary
AU  - Roy H
FAU - Wahab, Afrin
AU  - Wahab A
FAU - Duman, Eileen
AU  - Duman E
FAU - Bajwa, Rajinder
AU  - Bajwa R
FAU - Padmanabhan, Swaminathan
AU  - Padmanabhan S
FAU - Becker, Joanne
AU  - Becker J
FAU - Barrett, A John
AU  - Barrett AJ
FAU - McCarthy, Philip L Jr
AU  - McCarthy PL Jr
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20051110
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR15 antigen)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Bone Marrow Transplantation
MH  - Child
MH  - Chronic Disease
MH  - Disease-Free Survival
MH  - Female
MH  - Graft vs Host Disease/etiology/*immunology
MH  - HLA-DR Antigens/*immunology
MH  - HLA-DR Serological Subtypes
MH  - Humans
MH  - Incidence
MH  - Leukemia, Myeloid/complications/*immunology/mortality/therapy
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/complications/*immunology/mortality/therapy
MH  - Retrospective Studies
MH  - Transplantation, Homologous
EDAT- 2005/11/12 09:00
MHDA- 2006/04/04 09:00
CRDT- 2005/11/12 09:00
PHST- 2005/11/12 09:00 [pubmed]
PHST- 2006/04/04 09:00 [medline]
PHST- 2005/11/12 09:00 [entrez]
AID - S0006-4971(20)63895-2 [pii]
AID - 10.1182/blood-2005-05-1958 [doi]
PST - ppublish
SO  - Blood. 2006 Mar 1;107(5):1970-3. doi: 10.1182/blood-2005-05-1958. Epub 2005 Nov 
      10.