PMID- 16284526
OWN - NLM
STAT- MEDLINE
DCOM- 20060123
LR  - 20221207
IS  - 1525-4135 (Print)
IS  - 1525-4135 (Linking)
VI  - 40
IP  - 5
DP  - 2005 Dec 15
TI  - Risk for HIV-1 infection associated with a common CXCL12 (SDF1) polymorphism and 
      CXCR4 variation in an African population.
PG  - 521-6
AB  - CXC chemokine ligand 12 (CXCL12), or stromal cell-derived factor 1 (SDF1), is the 
      only known natural ligand for the HIV-1 coreceptor, CXC chemokine receptor 4 
      (CXCR4). A single nucleotide polymorphism (SNP) in the CXCL12 gene (SDF1-3'A) has 
      been associated with disease progression to AIDS in some studies, but not others. 
      Mutations in the CXCR4 gene are generally rare and have not been implicated in 
      HIV-1/AIDS pathogenesis. This study analyzed the SDF1-3'A SNP and performed 
      mutation screening for polymorphic markers in the CXCR4 gene to determine the 
      presence or absence of significant associations with susceptibility to HIV-1 
      infection. The study consisted of 257 HIV-1-seropositive patients and 113 
      HIV-1-seronegative controls representing a sub-Saharan African population 
      belonging to the Xhosa ethnic group of South Africa. The SDF1-3'A SNP was 
      associated with an increased risk for HIV-1 infection (P = 0.0319) whereas no 
      significant association was observed between the occurrence of the SDF1-3'A SNP 
      and increased or decreased plasma levels of CXCL12. Comprehensive mutation 
      analysis of the CXCR4 gene confirmed a high degree of genetic conservation within 
      the coding region of this ancient population.
FAU - Petersen, Desiree C
AU  - Petersen DC
AD  - Department of Medical Virology, University of Stellenbosch, Tygerberg Medical 
      School, South Africa.
FAU - Glashoff, Richard H
AU  - Glashoff RH
FAU - Shrestha, Sadeep
AU  - Shrestha S
FAU - Bergeron, Julie
AU  - Bergeron J
FAU - Laten, Annette
AU  - Laten A
FAU - Gold, Bert
AU  - Gold B
FAU - van Rensburg, Estrelita Janse
AU  - van Rensburg EJ
FAU - Dean, Michael
AU  - Dean M
FAU - Hayes, Vanessa M
AU  - Hayes VM
LA  - eng
SI  - OMIM/162643
SI  - OMIM/600835
GR  - N01CO12400/CA/NCI NIH HHS/United States
GR  - N01-CO-12400/CO/NCI NIH HHS/United States
GR  - Z01 BC005652-15/BC/NCI NIH HHS/United States
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (CXCL12 protein, human)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Chemokines, CXC)
RN  - 0 (Receptors, CXCR4)
SB  - IM
MH  - *Black People
MH  - Chemokine CXCL12
MH  - Chemokines, CXC/*genetics
MH  - *Genetic Variation
MH  - Genotype
MH  - HIV Infections/ethnology/*genetics/physiopathology
MH  - HIV-1/pathogenicity
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
MH  - Receptors, CXCR4/*genetics
MH  - Risk Factors
MH  - South Africa/epidemiology
PMC - PMC1369993
MID - NIHMS8262
EDAT- 2005/11/15 09:00
MHDA- 2006/01/24 09:00
PMCR- 2008/01/25
CRDT- 2005/11/15 09:00
PHST- 2005/11/15 09:00 [pubmed]
PHST- 2006/01/24 09:00 [medline]
PHST- 2005/11/15 09:00 [entrez]
PHST- 2008/01/25 00:00 [pmc-release]
AID - 00126334-200512150-00003 [pii]
AID - 10.1097/01.qai.0000186360.42834.28 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2005 Dec 15;40(5):521-6. doi: 
      10.1097/01.qai.0000186360.42834.28.