PMID- 16287152
OWN - NLM
STAT- MEDLINE
DCOM- 20060119
LR  - 20061115
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 104
IP  - 12
DP  - 2005 Dec 15
TI  - Pancreatic juice cytology in the diagnosis of intraductal papillary mucinous 
      neoplasm of the pancreas: significance of sampling by peroral pancreatoscopy.
PG  - 2830-6
AB  - BACKGROUND: The examination of pancreatic juice cytology could hypothetically 
      contribute to the establishment of a definite diagnosis of malignant intraductal 
      papillary mucinous neoplasm of the pancreas (IPMN), but to the authors' 
      knowledge, its significance has not been confirmed to date. The current study was 
      conducted to assess the diagnostic value of pancreatic juice cytology in IPMN and 
      to examine the usefulness of peroral pancreatoscopy (POPS) in sampling pancreatic 
      juice. METHODS: The study subjects were comprised of 103 patients with IPMN who 
      underwent surgical resection of pancreatic tumors (adenoma in 29 patients, 
      borderline in 17 patients, carcinoma in situ in 25 patients, and invasive 
      carcinoma in 32 patients). Pancreatic juice was collected with a catheter in 71 
      patients and by POPS in 32 patients. Patients with pancreatic carcinoma (n = 81) 
      and chronic pancreatitis (n = 76) also were investigated. RESULTS: The cytologic 
      diagnosis was found to be of nondiagnostic value in only one patient with an 
      IPMN, whereas it was of no diagnostic value in 14 of the patients with pancreatic 
      carcinoma (17.3%), a difference that was statically significant (P < 0.001). The 
      location of the IPMN (either in the pancreas or the pancreatic ducts) was not 
      found to significantly affect the diagnostic value of the test. The sensitivity 
      for IPMN was 62.2% when pancreatic juice was collected by POPS, and was 38.2% 
      when it was collected using a catheter. In the case of pancreatic carcinoma, the 
      sensitivity of pancreatic juice cytology was found to be 25.4%, which was 
      significantly lower than that for IPMN when the pancreatic juice was collected by 
      POPS (P < 0.001). CONCLUSIONS: Pancreatic juice cytology was found to have better 
      diagnostic value in the patients with IPMNs compared with those with pancreatic 
      carcinoma. POPS was found to be useful for the collection of pancreatic juice.
CI  - Copyright 2005 American Cancer Society.
FAU - Yamaguchi, Taketo
AU  - Yamaguchi T
AD  - Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba 
      University, Japan. yama.take@faculty.chiba-u.jp
FAU - Shirai, Yoshihiko
AU  - Shirai Y
FAU - Ishihara, Takeshi
AU  - Ishihara T
FAU - Sudo, Kentarou
AU  - Sudo K
FAU - Nakagawa, Akihiko
AU  - Nakagawa A
FAU - Ito, Hiroshi
AU  - Ito H
FAU - Miyazaki, Masaru
AU  - Miyazaki M
FAU - Nomura, Fumio
AU  - Nomura F
FAU - Saisho, Hiromitsu
AU  - Saisho H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - Adenocarcinoma, Mucinous/diagnosis/*pathology
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Pancreatic Ductal/diagnosis/*pathology
MH  - Carcinoma, Papillary/diagnosis/*pathology
MH  - Cholangiopancreatography, Endoscopic Retrograde/methods
MH  - Cohort Studies
MH  - Cytodiagnosis/methods
MH  - Diagnosis, Differential
MH  - Endoscopy, Digestive System/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Pancreatic Juice/*cytology
MH  - Pancreatic Neoplasms/diagnosis/*pathology
MH  - Prognosis
MH  - Reference Values
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Sensitivity and Specificity
EDAT- 2005/11/16 09:00
MHDA- 2006/01/20 09:00
CRDT- 2005/11/16 09:00
PHST- 2005/11/16 09:00 [pubmed]
PHST- 2006/01/20 09:00 [medline]
PHST- 2005/11/16 09:00 [entrez]
AID - 10.1002/cncr.21565 [doi]
PST - ppublish
SO  - Cancer. 2005 Dec 15;104(12):2830-6. doi: 10.1002/cncr.21565.