PMID- 16287226
OWN - NLM
STAT- MEDLINE
DCOM- 20060123
LR  - 20131121
IS  - 1043-1802 (Print)
IS  - 1043-1802 (Linking)
VI  - 16
IP  - 6
DP  - 2005 Nov-Dec
TI  - Polyketal nanoparticles: a new pH-sensitive biodegradable drug delivery vehicle.
PG  - 1340-2
AB  - In this report, we present an acid-sensitive drug delivery vehicle, termed 
      polyketal nanoparticles, which are designed to target therapeutics to the acidic 
      environments of tumors, inflammatory tissues, and phagosomes. The polyketal 
      nanoparticles are formulated from poly(1,4-phenyleneacetone dimethylene ketal) 
      (PPADK), a new hydrophobic polymer which contains ketal linkages in its backbone. 
      The polyketal nanoparticles undergo acid-catalyzed hydrolysis into low molecular 
      weight hydrophilic compounds and should therefore release encapsulated 
      therapeutics at an accelerated rate in acidic environments. Importantly, the 
      polyketal nanoparticles do not generate acidic degradation products after 
      hydrolysis, as with polyester-based biomaterials. Dexamethasone-loaded 
      nanoparticles, 200-600 nm in diameter, were fabricated with PPADK via an emulsion 
      procedure using chloroform and water. The hydrolysis half-life of PPADK was 
      measured to be 102 h at pH 7.4 and 35 h at pH 5.0. PPADK was synthesized by a new 
      polymerization strategy based on the acetal exchange reaction. This new delivery 
      system should find numerous applications in the field of drug delivery because of 
      its ease of synthesis and excellent degradation properties.
FAU - Heffernan, Michael J
AU  - Heffernan MJ
AD  - The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of 
      Technology, Atlanta, Georgia 30332, USA.
FAU - Murthy, Niren
AU  - Murthy N
LA  - eng
GR  - UO1 HL80711-01/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Bioconjug Chem
JT  - Bioconjugate chemistry
JID - 9010319
RN  - 0 (Polymers)
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
MH  - Biodegradation, Environmental
MH  - Dexamethasone/administration & dosage
MH  - Drug Delivery Systems/*methods
MH  - Half-Life
MH  - Hydrogen-Ion Concentration
MH  - Hydrolysis
MH  - *Nanostructures
MH  - *Polymers/pharmacokinetics
EDAT- 2005/11/17 09:00
MHDA- 2006/01/24 09:00
CRDT- 2005/11/17 09:00
PHST- 2005/11/17 09:00 [pubmed]
PHST- 2006/01/24 09:00 [medline]
PHST- 2005/11/17 09:00 [entrez]
AID - 10.1021/bc050176w [doi]
PST - ppublish
SO  - Bioconjug Chem. 2005 Nov-Dec;16(6):1340-2. doi: 10.1021/bc050176w.