PMID- 16287297
OWN - NLM
STAT- MEDLINE
DCOM- 20060214
LR  - 20161124
IS  - 0002-7863 (Print)
IS  - 0002-7863 (Linking)
VI  - 127
IP  - 46
DP  - 2005 Nov 23
TI  - Photoswitched cell adhesion on surfaces with RGD peptides.
PG  - 16107-10
AB  - Coating of surfaces by RGD peptides is well-known. Herein we describe the 
      possibility to switch cell adhesion properties by changing the distance and 
      orientation of the RGD peptides to the surface. A set of RGD peptides of the type 
      cyclo(-RGDfK-) was synthesized containing the photoswitchable 
      4-[(4-aminophenyl)azo]benzocarbonyl central unit as spacer between the acrylamide 
      anchor and the RGD peptide. PMMA (poly methyl methacrylate) surfaces were coated 
      with these peptides. Control of adhesion stimulation by irradiation with 366 or 
      450 nm light could be achieved.
FAU - Auernheimer, Jorg
AU  - Auernheimer J
AD  - Department Chemie, Lehrstuhl II fur Organische Chemie, Technische Universitat 
      Munchen, Lichtenbergstr. 4, D-85747 Garching, Germany.
FAU - Dahmen, Claudia
AU  - Dahmen C
FAU - Hersel, Ulrich
AU  - Hersel U
FAU - Bausch, Andreas
AU  - Bausch A
FAU - Kessler, Horst
AU  - Kessler H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Chem Soc
JT  - Journal of the American Chemical Society
JID - 7503056
RN  - 0 (Oligopeptides)
RN  - 78VO7F77PN (arginyl-glycyl-aspartic acid)
SB  - IM
MH  - Animals
MH  - Cell Adhesion/drug effects
MH  - Cell Line
MH  - Mice
MH  - Molecular Structure
MH  - Oligopeptides/*chemistry/*pharmacology
MH  - Photochemistry
MH  - Spectrum Analysis
EDAT- 2005/11/17 09:00
MHDA- 2006/02/16 09:00
CRDT- 2005/11/17 09:00
PHST- 2005/11/17 09:00 [pubmed]
PHST- 2006/02/16 09:00 [medline]
PHST- 2005/11/17 09:00 [entrez]
AID - 10.1021/ja053648q [doi]
PST - ppublish
SO  - J Am Chem Soc. 2005 Nov 23;127(46):16107-10. doi: 10.1021/ja053648q.