PMID- 16290992
OWN - NLM
STAT- MEDLINE
DCOM- 20051229
LR  - 20161122
IS  - 1097-6744 (Electronic)
IS  - 0002-8703 (Linking)
VI  - 150
IP  - 5
DP  - 2005 Nov
TI  - The relationship between C-reactive protein and subclinical cardiovascular 
      disease in the Diabetes Heart Study (DHS).
PG  - 1032-8
AB  - BACKGROUND: Epidemiological studies suggest that levels of C-reactive protein 
      (CRP) predict cardiovascular disease (CVD). We have evaluated the relationship 
      between CRP and subclinical CVD in a study cohort at high risk of CVD. METHODS: 
      The DHS is a single-center, family-based study of the genetic and environmental 
      components of CVD in type 2 diabetes mellitus (T2DM). We evaluated 666 subjects 
      (551 T2DM affected and 115 unaffected) with an average age of 61 years. Measures 
      of coronary artery calcium (CAC), intimal-medial thickness (IMT) of the common 
      carotid artery, and CRP were obtained on all subjects. RESULTS: C-reactive 
      protein is positively and significantly associated with female sex, body mass 
      index, and smoking and is negatively and significantly associated with age and 
      statin use. Generalized estimating equations were used to test whether CRP was 
      associated with each subclinical CVD measure (presence/absence of CAC, quantity 
      of CAC, and IMT) adjusting for covariates and correlation among siblings. 
      Stratified analyses were conducted to examine whether these associations differed 
      across sex and statin use. In the overall analysis, CRP was not significantly 
      associated with IMT or presence of CAC but was negatively and significantly 
      associated with quantity of CAC (P = .01). When covariates were added, the 
      relationship was no longer significant. Similar patterns were observed in 
      stratified analyses based on sex, statin use, and diabetes status: weak but 
      negative association of CAC with CRP, which became nonsignificant with adjustment 
      for covariates. CONCLUSIONS: In a population at high risk for CVD, there was no 
      evidence of incremental association of CRP levels with measures of subclinical 
      CVD.
FAU - Bowden, Donald W
AU  - Bowden DW
AD  - Department of Biochemistry, Wake Forest University School of Medicine, 
      Winston-Salem, NC 27157, USA. dbowden@wfubmc.edu
FAU - Lange, Leslie A
AU  - Lange LA
FAU - Langefeld, Carl D
AU  - Langefeld CD
FAU - Brosnihan, K Bridget
AU  - Brosnihan KB
FAU - Freedman, Barry I
AU  - Freedman BI
FAU - Carr, J Jeffrey
AU  - Carr JJ
FAU - Wagenknecht, Lynne E
AU  - Wagenknecht LE
FAU - Herrington, David M
AU  - Herrington DM
LA  - eng
GR  - R01 HL67348/HL/NHLBI NIH HHS/United States
GR  - M01 RR007122-140204/RR/NCRR NIH HHS/United States
GR  - R01 AR048797-03/AR/NIAMS NIH HHS/United States
GR  - R01 AR048797/AR/NIAMS NIH HHS/United States
GR  - M01 RR007122-150204/RR/NCRR NIH HHS/United States
GR  - R01 AR048797-02/AR/NIAMS NIH HHS/United States
GR  - R01 AR048797-01/AR/NIAMS NIH HHS/United States
GR  - M01 RR007122/RR/NCRR NIH HHS/United States
GR  - M01 RR07122/RR/NCRR NIH HHS/United States
GR  - M01 RR007122-130204/RR/NCRR NIH HHS/United States
GR  - R01 AR048797-04/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - C-Reactive Protein/*analysis
MH  - Cardiovascular Diseases/*blood
MH  - Diabetes Complications/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2005/11/18 09:00
MHDA- 2005/12/31 09:00
CRDT- 2005/11/18 09:00
PHST- 2004/06/16 00:00 [received]
PHST- 2005/01/04 00:00 [accepted]
PHST- 2005/11/18 09:00 [pubmed]
PHST- 2005/12/31 09:00 [medline]
PHST- 2005/11/18 09:00 [entrez]
AID - S0002-8703(05)00043-8 [pii]
AID - 10.1016/j.ahj.2005.01.017 [doi]
PST - ppublish
SO  - Am Heart J. 2005 Nov;150(5):1032-8. doi: 10.1016/j.ahj.2005.01.017.