PMID- 16292641
OWN - NLM
STAT- MEDLINE
DCOM- 20070501
LR  - 20181113
IS  - 0014-4819 (Print)
IS  - 0014-4819 (Linking)
VI  - 169
IP  - 4
DP  - 2006 Mar
TI  - Ketamine attenuates glutamate-induced mechanical sensitization of the masseter 
      muscle in human males.
PG  - 467-72
AB  - The purpose of the present study was to determine whether glutamate-induced 
      mechanical sensitization of the masseter muscle in human volunteers involves 
      activation of peripheral N-methyl-D-aspartate (NMDA) receptors. Healthy male 
      volunteers (n=18) participated in this randomized, two-session study. During each 
      session, the volunteers received two injections into the right masseter muscle. 
      An initial injection of glutamate (1 M, 0.2 ml) alone was followed 30 min later 
      by a second injection of glutamate alone or glutamate combined with ketamine (10 
      mM). Pressure pain threshold (PPT) was assessed over the right masseter muscle at 
      and 2 cm above the injection site, as well as over the right temporalis muscle 
      and left masseter muscle prior to the first injection. The PPT was reassessed at 
      all four sites every 5 min from 10 to 30 min after the second injection and once 
      again 60 min after the second injection. Glutamate-evoked muscle pain, pain area 
      and the sensory pain response index of the McGill pain questionnaire were all 
      significantly reduced by co-injection of ketamine. The mean PPT values were 
      significantly decreased by approximately 10%, 10, 15 and 25 min after injection 
      of glutamate, but only over the site of injection. Co-injection of ketamine with 
      glutamate also completely blocked the glutamate-induced mechanical sensitization 
      15 min post-injection as compared with glutamate alone. The lack of spread of 
      mechanical sensitization outside the area of glutamate injection is consistent 
      with the view that glutamate-induced mechanical sensitization results from a 
      peripheral mechanism. The attenuation of glutamate-induced mechanical 
      sensitization by ketamine suggests that this effect is mediated, in part, through 
      activation of peripheral NMDA receptors.
FAU - Cairns, Brian E
AU  - Cairns BE
AD  - Orofacial Pain Laboratory, Center for Sensory-Motor Interaction, Aalborg 
      University, 9220 Aalborg, Denmark. brcairns@interchange.ubc.ca
FAU - Svensson, Peter
AU  - Svensson P
FAU - Wang, Kelun
AU  - Wang K
FAU - Castrillon, Eduardo
AU  - Castrillon E
FAU - Hupfeld, Steen
AU  - Hupfeld S
FAU - Sessle, Barry J
AU  - Sessle BJ
FAU - Arendt-Nielsen, Lars
AU  - Arendt-Nielsen L
LA  - eng
GR  - DE15420/DE/NIDCR NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20051116
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 690G0D6V8H (Ketamine)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Double-Blind Method
MH  - Drug Interactions
MH  - Excitatory Amino Acid Antagonists/*pharmacology
MH  - Functional Laterality
MH  - Glutamic Acid/*pharmacology
MH  - Humans
MH  - Ketamine/*pharmacology
MH  - Male
MH  - Masseter Muscle/*drug effects
MH  - Pain Measurement
MH  - Pain Threshold/*drug effects
MH  - Pressure/adverse effects
MH  - Time Factors
EDAT- 2005/11/18 09:00
MHDA- 2007/05/02 09:00
CRDT- 2005/11/18 09:00
PHST- 2005/03/14 00:00 [received]
PHST- 2005/07/06 00:00 [accepted]
PHST- 2005/11/18 09:00 [pubmed]
PHST- 2007/05/02 09:00 [medline]
PHST- 2005/11/18 09:00 [entrez]
AID - 10.1007/s00221-005-0158-z [doi]
PST - ppublish
SO  - Exp Brain Res. 2006 Mar;169(4):467-72. doi: 10.1007/s00221-005-0158-z. Epub 2005 
      Nov 16.