PMID- 16295048
OWN - NLM
STAT- MEDLINE
DCOM- 20051212
LR  - 20061115
IS  - 0394-3402 (Print)
IS  - 0394-3402 (Linking)
VI  - 17
IP  - 5
DP  - 2004 Oct
TI  - Apolipoprotein E polymorphism in Turkish subjects with Type 2 diabetes mellitus: 
      allele frequency and relation to serum lipid concentrations.
PG  - 267-74
AB  - The role of apolipoprotein E (apoE) genotypes in modulating plasma lipid and 
      apolipoprotein levels was studied in 112 patients with Type 2 diabetes mellitus 
      (T2DM) and 94 healthy individuals. ApoE genotypes were identified by PCR 
      amplification and subsequent restriction endonuclease digestion. The apoE allele 
      and genotype frequencies were similar in both the diabetic and control subjects. 
      The apoE allele frequencies were found to be 74.3 for e3, 10.1 for e2, 15.6 for 
      e4 in the diabetic group, and 68.1 for e3, 13.2 for e2 and 18.7 for e4 in the 
      control group. Sex-specific genotypic distribution of apoE polymorphism did not 
      differ between the study groups. To elucidate the association of apoE with lipid 
      abnormalities with respect to gender, serum lipid and apolipoprotein levels were 
      compared among apo e2 (e2/2 and e3/2), e3 (e3/3) and e4 (e4/3 and e4/4) groups of 
      T2DM and control subjects. Apo e2 allele was found to be associated to 
      triglycerides for both sexes, and associated to glucose, and BMI only in females. 
      Subjects with e2 allele had higher levels of BMI, glucose and triglyceride in 
      comparison to e3 and e4. Our data suggest that genetic variation at the apoE 
      locus in Turkish subjects is a genetic factor that influences lipid levels. 
      Further studies attempting to correlate apoE polymorphism with lipid profile in a 
      large number of individuals would be helpful in establishing the true 
      significance of this polymorphism in the Turkish population.
FAU - Duman, B Susleyici
AU  - Duman BS
AD  - Medical Biology and Genetics Department, Medical Faculty, Kadir Has University, 
      School of Medicine, Gayrettepe-Istanbul, Turkey. bsusleyici@khas.edu.tr
FAU - Ozturk, M
AU  - Ozturk M
FAU - Yilmazer, S
AU  - Yilmazer S
FAU - Hatemi, H
AU  - Hatemi H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - Diabetes Nutr Metab
JT  - Diabetes, nutrition & metabolism
JID - 8813443
RN  - 0 (Apolipoproteins)
RN  - 0 (Apolipoproteins E)
RN  - 0 (Blood Glucose)
RN  - 0 (Lipids)
RN  - 0 (Triglycerides)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Analysis of Variance
MH  - Apolipoproteins/blood
MH  - Apolipoproteins E/blood/*genetics
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - DNA/chemistry
MH  - Diabetes Mellitus, Type 2/blood/*genetics
MH  - Female
MH  - *Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Lipids/*blood
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Restriction Mapping
MH  - Sex Distribution
MH  - Triglycerides/blood
MH  - Turkey
EDAT- 2005/11/22 09:00
MHDA- 2005/12/15 09:00
CRDT- 2005/11/22 09:00
PHST- 2005/11/22 09:00 [pubmed]
PHST- 2005/12/15 09:00 [medline]
PHST- 2005/11/22 09:00 [entrez]
PST - ppublish
SO  - Diabetes Nutr Metab. 2004 Oct;17(5):267-74.