PMID- 16295049
OWN - NLM
STAT- MEDLINE
DCOM- 20051212
LR  - 20221207
IS  - 0394-3402 (Print)
IS  - 0394-3402 (Linking)
VI  - 17
IP  - 5
DP  - 2004 Oct
TI  - Glycemic optimization may reduce lipid peroxidation independent of weight and 
      blood lipid changes in Type 2 diabetes mellitus.
PG  - 275-9
AB  - The aim of this study was to determine the effect of diet-therapy on lipid 
      peroxidation in patients with Type 2 diabetes mellitus (T2DM). Fifteen T2DM 
      patients of both sexes, aged between 35-70 years, were given the diet suggested 
      for patients with diabetes by the American Diabetic Association. This diet 
      comprised 50-60% carbohydrate, 10-15% protein, 20-30% fat and about 35 g fiber 
      was given for weight maintenance. Weight and body mass index did not change 
      significantly during 8 weeks of study. Also, no statistically significant 
      difference was observed in serum total cholesterol, triglycerides, LDL- and 
      HDL-cholesterol from before to after dietary intervention. However, the levels of 
      fasting blood sugar, HbA1c and malondialdehyde were lowered significantly after 
      dietary intervention. It was concluded that glycemic optimization, independent of 
      weight and blood lipid profile, through a well-designed diet is likely to be the 
      most effective factor in reducing the process of oxidative stress in T2DM. This 
      may have preventive implications for such diabetic complications as 
      atherosclerosis.
FAU - Neyestani, T R
AU  - Neyestani TR
AD  - Laboratory of Nutrition Research, National Institute of Nutrition Research and 
      Food Technology, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. 
      tneyestani@nnftri.ac.ir
FAU - Alipour-Birgani, R
AU  - Alipour-Birgani R
FAU - Siassi, F
AU  - Siassi F
FAU - Rajayi, M
AU  - Rajayi M
FAU - Djalali, M
AU  - Djalali M
FAU - Mohamadi, M
AU  - Mohamadi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - Diabetes Nutr Metab
JT  - Diabetes, nutrition & metabolism
JID - 8813443
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Lipids)
RN  - 4Y8F71G49Q (Malondialdehyde)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Atherosclerosis/prevention & control
MH  - Blood Glucose/*metabolism
MH  - Body Mass Index
MH  - Body Weight
MH  - Diabetes Mellitus, Type 2/blood/*diet therapy/metabolism
MH  - Diabetic Angiopathies/prevention & control
MH  - *Diet, Diabetic
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - *Lipid Peroxidation
MH  - Lipids/blood
MH  - Male
MH  - Malondialdehyde/blood
MH  - Middle Aged
MH  - Oxidative Stress
EDAT- 2005/11/22 09:00
MHDA- 2005/12/15 09:00
CRDT- 2005/11/22 09:00
PHST- 2005/11/22 09:00 [pubmed]
PHST- 2005/12/15 09:00 [medline]
PHST- 2005/11/22 09:00 [entrez]
PST - ppublish
SO  - Diabetes Nutr Metab. 2004 Oct;17(5):275-9.