PMID- 16297164
OWN - NLM
STAT- MEDLINE
DCOM- 20060113
LR  - 20181113
IS  - 0009-9104 (Print)
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Linking)
VI  - 142
IP  - 3
DP  - 2005 Dec
TI  - The association of anti-phospholipid antibodies with parity in placental malaria.
PG  - 512-8
AB  - Anti-phospholipid antibodies (aPL) are autoantibodies associated with both 
      infections and the pathogenesis of certain pregnancy complications. In the 
      latter, but not the former, aPL are dependent on a co-factor, beta(2) 
      glycoprotein I (beta2GPI), which can also be used as an antigen for detection of 
      such aPL in pregnancy. A cross-sectional study was carried out on serum samples 
      from Kumasi, Ghana, to determine the occurrence and beta2GPI-dependence of aPL in 
      placental malaria. Anti-cardiolipin, anti-phosphatidylserine and anti-beta2GPI 
      enzyme-linked immunosorbent assays (ELISAs) were performed on sera from 103 
      HIV-non-infected gravid women. Placental malaria, both active and past infection, 
      was diagnosed in 33/103 (32%) based on placental histology. In multiparae, 
      beta2GPI-independent IgM antibodies to cardiolipin (P = 0.018) and 
      phosphatidylserine (P = 0.009) were observed, which were most pronounced in past 
      placental malaria infection. In primiparae, no association emerged between aPL 
      and placental malaria. Trends for improved clinical parameters were identified in 
      infected women with levels of anti-cardiolipin beyond the 99th multiple of the 
      median for a healthy, non-malarious population. This study in placental malaria 
      reports parity associations of beta2GPI-independent aPL profiles, and does not 
      support a role for beta2GPI-dependent aPL. It is of significance in the context 
      of the known parity differences in pregnancy malaria immunity.
FAU - Owens, S
AU  - Owens S
AD  - MRC Laboratories, Atlantic Road, Fajara, The Gambia.
FAU - Chamley, L W
AU  - Chamley LW
FAU - Ordi, J
AU  - Ordi J
FAU - Brabin, B J
AU  - Brabin BJ
FAU - Johnson, P M
AU  - Johnson PM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Antibodies, Anticardiolipin)
RN  - 0 (Antibodies, Antiphospholipid)
RN  - 0 (Anticoagulants)
RN  - 0 (Apolipoproteins)
RN  - 0 (Cardiolipins)
RN  - 0 (Glycoproteins)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Phosphatidylserines)
RN  - 0 (beta 2-Glycoprotein I)
SB  - IM
MH  - Adult
MH  - Antibodies, Anticardiolipin/immunology
MH  - Antibodies, Antiphospholipid/*immunology
MH  - Anticoagulants/immunology
MH  - Apolipoproteins/immunology
MH  - Cardiolipins/immunology
MH  - Cross-Sectional Studies
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Female
MH  - Glycoproteins/immunology
MH  - Humans
MH  - Immunoglobulin G/analysis
MH  - Malaria/*immunology
MH  - Parity/*immunology
MH  - Phosphatidylserines/immunology
MH  - Placenta Diseases/*immunology
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/*immunology
MH  - beta 2-Glycoprotein I
PMC - PMC1809541
EDAT- 2005/11/22 09:00
MHDA- 2006/01/18 09:00
PMCR- 2006/12/01
CRDT- 2005/11/22 09:00
PHST- 2005/11/22 09:00 [pubmed]
PHST- 2006/01/18 09:00 [medline]
PHST- 2005/11/22 09:00 [entrez]
PHST- 2006/12/01 00:00 [pmc-release]
AID - CEI2936 [pii]
AID - 10.1111/j.1365-2249.2005.02936.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2005 Dec;142(3):512-8. doi: 10.1111/j.1365-2249.2005.02936.x.