PMID- 16297197
OWN - NLM
STAT- MEDLINE
DCOM- 20060120
LR  - 20121115
IS  - 0022-202X (Print)
IS  - 0022-202X (Linking)
VI  - 125
IP  - 5
DP  - 2005 Nov
TI  - Cutaneous, but not airway, latex exposure induces allergic lung inflammation and 
      airway hyperreactivity in mice.
PG  - 962-8
AB  - As respiratory symptoms are common in addition to skin reactions in natural 
      rubber latex allergy, we investigated the significance of different allergen 
      exposure routes in the development of lung inflammation and airway 
      hyperreactivity (AHR). Both intracutaneous (IC) and intraperitoneal (IP) exposure 
      followed by airway challenge with latex proteins induced an influx of mononuclear 
      cells and eosinophils to the lungs. AHR and lung mucus production increased 
      significantly after IC and IP but not after intranasal (IN) exposure. 
      Infiltration of inflammatory cells was associated with the induction of T-helper 
      type 2 (Th2) cytokines and several CC chemokines. Only a marginal induction of 
      these mediators was found after IN exposure. On the contrary, increased levels of 
      transforming growth factor-beta1 and forkhead box 3 mRNA, markers of regulatory 
      activities, were found in the lungs after IN but not after IC exposure. Finally, 
      IC and IP, but not IN, latex exposure induced a striking increase in specific 
      immunoglobulin E (IgE) levels. Cutaneous latex exposure in the absence of 
      adjuvant followed by airway challenge induces a local Th2-dominated lung 
      inflammation and a systemic IgE response. Cutaneous exposure to proteins eluting 
      from latex products may therefore profoundly contribute to the development of 
      asthma in latex allergy.
FAU - Lehto, Maili
AU  - Lehto M
AD  - Department of Industrial Hygiene and Toxicology, Finnish Institute of 
      Occupational Health, Helsinki, Finland.
FAU - Haapakoski, Rita
AU  - Haapakoski R
FAU - Wolff, Henrik
AU  - Wolff H
FAU - Majuri, Marja-Leena
AU  - Majuri ML
FAU - Makela, Mika J
AU  - Makela MJ
FAU - Leino, Marina
AU  - Leino M
FAU - Reunala, Timo
AU  - Reunala T
FAU - Turjanmaa, Kristiina
AU  - Turjanmaa K
FAU - Palosuo, Timo
AU  - Palosuo T
FAU - Alenius, Harri
AU  - Alenius H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 0 (Allergens)
RN  - 0 (Antigens, Plant)
RN  - 0 (Chemokines, CC)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxp3 protein, mouse)
RN  - 0 (Hev b 6.01 protein, Hevea brasiliensis)
RN  - 0 (Latex)
RN  - 0 (Plant Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tgfb1 protein, mouse)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Administration, Cutaneous
MH  - Administration, Intranasal
MH  - Allergens/administration & dosage/*immunology
MH  - Animals
MH  - Antigens, Plant
MH  - Chemokines, CC/genetics/metabolism
MH  - Eosinophils/immunology
MH  - Forkhead Transcription Factors/genetics/metabolism
MH  - Immunoglobulin E/blood/immunology
MH  - Latex/administration & dosage/*immunology
MH  - Latex Hypersensitivity/*immunology
MH  - Lung/immunology
MH  - Mice
MH  - Plant Proteins/immunology
MH  - Pneumonia/*immunology
MH  - RNA, Messenger/analysis/metabolism
MH  - Respiratory Hypersensitivity/*immunology
MH  - Skin/immunology
MH  - Th2 Cells/immunology/metabolism
MH  - Transforming Growth Factor beta/genetics/metabolism
MH  - Transforming Growth Factor beta1
MH  - Up-Regulation
EDAT- 2005/11/22 09:00
MHDA- 2006/01/21 09:00
CRDT- 2005/11/22 09:00
PHST- 2005/11/22 09:00 [pubmed]
PHST- 2006/01/21 09:00 [medline]
PHST- 2005/11/22 09:00 [entrez]
AID - S0022-202X(15)32504-5 [pii]
AID - 10.1111/j.0022-202X.2005.23910.x [doi]
PST - ppublish
SO  - J Invest Dermatol. 2005 Nov;125(5):962-8. doi: 10.1111/j.0022-202X.2005.23910.x.