PMID- 16297566
OWN - NLM
STAT- MEDLINE
DCOM- 20060412
LR  - 20131121
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 137
IP  - 3
DP  - 2006 Feb
TI  - Quantitative analysis of glutamate transporter mRNA expression in prefrontal and 
      primary visual cortex in normal and schizophrenic brain.
PG  - 843-51
AB  - Abnormalities of the glutamatergic system in schizophrenia have been identified 
      in numerous studies, but little is known about the role of glutamate transporters 
      and their messenger RNA (mRNA) expression. In addition, the abundances of the two 
      major isoforms of human excitatory amino acid transporter 2 (EAAT2) or its rat 
      ortholog, glutamate transporter 1, have never been compared in a quantitative 
      manner. Using quantitative reverse transcription-polymerase chain reaction, we 
      established that the expression of the EAAT1, EAAT2a, EAAT2b, and EAAT3 
      transcripts was not different in the dorsolateral prefrontal and primary visual 
      cortices of persons with schizophrenia relative to matched controls. EAAT2a 
      expression was about 25-fold and 10-fold higher than EAAT2b in human and rat 
      brain, respectively. The data provided no evidence of an effect of antipsychotic 
      medications on the mRNA expression of the glutamate transporters. However, 
      because most of the schizophrenic subjects in the cohort had been treated with 
      antipsychotics for many years, it is still possible that changes in transporter 
      expression were masked by medication effects.
FAU - Lauriat, T L
AU  - Lauriat TL
AD  - Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy 
      Place, Box 1229, New York, NY 10029, USA.
FAU - Dracheva, S
AU  - Dracheva S
FAU - Chin, B
AU  - Chin B
FAU - Schmeidler, J
AU  - Schmeidler J
FAU - McInnes, L A
AU  - McInnes LA
FAU - Haroutunian, V
AU  - Haroutunian V
LA  - eng
PT  - Journal Article
DEP - 20051116
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Actins)
RN  - 0 (Amino Acid Transport System X-AG)
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Excitatory Amino Acid Transporter 1)
RN  - 0 (Excitatory Amino Acid Transporter 4)
RN  - 0 (Excitatory Amino Acid Transporter 5)
RN  - 0 (RNA, Messenger)
RN  - 0 (Slc1a3 protein, rat)
RN  - 0 (Slc1a6 protein, rat)
RN  - 0 (Slc1a7 protein, rat)
RN  - J6292F8L3D (Haloperidol)
SB  - IM
MH  - Actins/biosynthesis
MH  - Amino Acid Transport System X-AG/*biosynthesis
MH  - Animals
MH  - Antipsychotic Agents/pharmacology
MH  - Excitatory Amino Acid Transporter 1/biosynthesis/genetics
MH  - Excitatory Amino Acid Transporter 4/biosynthesis/genetics
MH  - Excitatory Amino Acid Transporter 5/biosynthesis/genetics
MH  - Haloperidol/pharmacology
MH  - Humans
MH  - Photoreceptor Cells
MH  - Prefrontal Cortex/drug effects/*metabolism
MH  - RNA, Messenger/analysis/*biosynthesis/isolation & purification
MH  - Rats
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Schizophrenia/*metabolism
MH  - Visual Cortex/drug effects/*metabolism
EDAT- 2005/11/22 09:00
MHDA- 2006/04/13 09:00
CRDT- 2005/11/22 09:00
PHST- 2005/05/24 00:00 [received]
PHST- 2005/08/19 00:00 [revised]
PHST- 2005/10/06 00:00 [accepted]
PHST- 2005/11/22 09:00 [pubmed]
PHST- 2006/04/13 09:00 [medline]
PHST- 2005/11/22 09:00 [entrez]
AID - S0306-4522(05)01122-X [pii]
AID - 10.1016/j.neuroscience.2005.10.003 [doi]
PST - ppublish
SO  - Neuroscience. 2006 Feb;137(3):843-51. doi: 10.1016/j.neuroscience.2005.10.003. 
      Epub 2005 Nov 16.