PMID- 16297977
OWN - NLM
STAT- MEDLINE
DCOM- 20060608
LR  - 20071115
IS  - 0145-2126 (Print)
IS  - 0145-2126 (Linking)
VI  - 30
IP  - 6
DP  - 2006 Jun
TI  - Korean patients with chronic lymphocytic leukemia show the similar types of 
      chromosomal aberrations as those in Europe and North America.
PG  - 695-9
AB  - Chronic lymphocytic leukemia (CLL) is frequent in the West, but rare in Korea. In 
      this study, the frequency of chromosome aberration in Korean CLL patients was 
      examined by applying interphase fluorescence in situ hybridization (FISH). 
      Conventional cytogenetic test and FISH were performed on bone marrow aspirates 
      obtained from 16 CLL patients. By applying DNA probes (Vysis, Downers Grove, IL, 
      USA), the deletion in 11q22-23, 13q14, 13q34, and 17p13, and trisomy 12 were 
      examined. With FISH, molecular cytogenetic aberration was detected in 10 of 16 
      patients [63%, 95% confidence interval (CI) 39-86], whereas with conventional 
      cytogenetic test, chromosomal aberration was detected only in 2 out of 13 cases 
      (15%, 95% CI 0-35). In total, the cases with one or more chromosomal aberrations 
      were 11 out of 16 cases (69%, 95% CI 46-92). The most frequently detected 
      aberration was the 13q14 deletion (69%, 95% CI 44-94), followed by trisomy 12 
      (19%, 95% CI 0-38) and 11q22 deletion (14%, 95% CI 0-33). No deletion in 17p13 
      was observed. In conclusion, CLL in Korean is a heterogeneous genetic disorder, 
      showing similar genetic changes in Europe and North America.
FAU - Chang, Yoon Hwan
AU  - Chang YH
AD  - Department of Laboratory Medicine, Korea Cancer Center Hospital, Korea Institute 
      of Radiological and Medical Sciences, and Department of Laboratory Medicine, 
      Seoul National University College of Medicine, Seoul, Republic of Korea.
FAU - Park, Junwan
AU  - Park J
FAU - Kim, Hee Chan
AU  - Kim HC
FAU - Chun, Hong Ku
AU  - Chun HK
FAU - Kim, Young Ree
AU  - Kim YR
FAU - Kim, Myungshin
AU  - Kim M
FAU - Han, Kyungja
AU  - Han K
FAU - Lee, Je-Hwan
AU  - Lee JH
FAU - Lee, Kyoo-Hyung
AU  - Lee KH
FAU - Cho, Han Ik
AU  - Cho HI
FAU - Lee, Yun Song
AU  - Lee YS
FAU - Lee, Dong Soon
AU  - Lee DS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051117
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
SB  - IM
MH  - Aged
MH  - *Chromosome Deletion
MH  - Chromosomes, Human/*genetics
MH  - Europe
MH  - Female
MH  - Humans
MH  - In Situ Hybridization
MH  - Korea
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/ethnology/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - North America
MH  - Trisomy/*genetics
EDAT- 2005/11/22 09:00
MHDA- 2006/06/09 09:00
CRDT- 2005/11/22 09:00
PHST- 2005/06/05 00:00 [received]
PHST- 2005/11/22 09:00 [pubmed]
PHST- 2006/06/09 09:00 [medline]
PHST- 2005/11/22 09:00 [entrez]
AID - S0145-2126(05)00399-1 [pii]
AID - 10.1016/j.leukres.2005.10.013 [doi]
PST - ppublish
SO  - Leuk Res. 2006 Jun;30(6):695-9. doi: 10.1016/j.leukres.2005.10.013. Epub 2005 Nov 
      17.