PMID- 16298431
OWN - NLM
STAT- MEDLINE
DCOM- 20080314
LR  - 20060131
IS  - 0165-2478 (Print)
IS  - 0165-2478 (Linking)
VI  - 103
IP  - 2
DP  - 2006 Mar 15
TI  - Immunization of susceptible mice with gp43-pulsed dendritic cells induce an 
      increase of pulmonary Paracoccidioidomycosis.
PG  - 121-6
AB  - The development of the appropriate CD4 Th subset is important for disease 
      resolution and several studies have shown that different outcomes of a disease 
      can be obtained by influencing the commitment of precursors to either, Th1 or Th2 
      lineage. Dendritic cells (DCs) are able to initiate response in naive T cells and 
      they also participate in Th cell education. In the present study we demonstrated 
      that purified gp43 lead to down-regulation of MHC-II and adhesion properties of 
      immature DCs and in LPS-induced DCs maturation. It was also shown that purified 
      gp43 from Paracoccidioides brasiliensis has the same inhibitory effect on IL-12 
      release. Mice infected with Paracoccidioides brasiliensis that received DCs plus 
      gp43 plus LPS had a significant increase of the lung colony forming units when 
      compared with control (not immunized) or those that received only DCs plus LPS. 
      Thus, the granuloma morphology seen in immunized mice was different when compared 
      with non-immunized controls. These data suggest that gp43 affects many functions 
      of the host cells, indicating that these alterations might be used by 
      Paracoccidioides brasiliensis to reduce the effectiveness of the immune response 
      thus facilitating the establishment and fate of primary infection in susceptible 
      host.
FAU - Ferreira, Karen Spadari
AU  - Ferreira KS
AD  - Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciencias 
      Farmaceuticas, Universidade de Sao Paulo, Avenida Prof. Lineu Prestes, 580, Bloco 
      17, Sao Paulo, CEP: 05508-900, Brazil.
FAU - Almeida, Sandro Rogerio
AU  - Almeida SR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20051108
PL  - Netherlands
TA  - Immunol Lett
JT  - Immunology letters
JID - 7910006
RN  - 0 (43 kDa protein, Paracoccidioides)
RN  - 0 (Antigens, Fungal)
RN  - 0 (Fungal Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Membrane Proteins)
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
MH  - Animals
MH  - Antigens, Fungal/*immunology
MH  - Dendritic Cells/*immunology/metabolism/transplantation
MH  - Female
MH  - Fungal Proteins/*immunology
MH  - Glycoproteins/*immunology
MH  - *Immunotherapy, Adoptive
MH  - Interleukin-12/biosynthesis
MH  - Lipopolysaccharides/immunology
MH  - Lung Diseases/*immunology/microbiology
MH  - Lymphocyte Activation/immunology
MH  - Membrane Proteins/biosynthesis/genetics
MH  - Mice
MH  - Paracoccidioides/immunology
MH  - Paracoccidioidomycosis/*immunology
MH  - Th1 Cells/immunology
MH  - Th2 Cells/immunology
EDAT- 2005/11/22 09:00
MHDA- 2008/03/15 09:00
CRDT- 2005/11/22 09:00
PHST- 2005/08/04 00:00 [received]
PHST- 2005/10/03 00:00 [revised]
PHST- 2005/10/18 00:00 [accepted]
PHST- 2005/11/22 09:00 [pubmed]
PHST- 2008/03/15 09:00 [medline]
PHST- 2005/11/22 09:00 [entrez]
AID - S0165-2478(05)00328-7 [pii]
AID - 10.1016/j.imlet.2005.10.014 [doi]
PST - ppublish
SO  - Immunol Lett. 2006 Mar 15;103(2):121-6. doi: 10.1016/j.imlet.2005.10.014. Epub 
      2005 Nov 8.