PMID- 16298748
OWN - NLM
STAT- MEDLINE
DCOM- 20060314
LR  - 20131121
IS  - 1071-5762 (Print)
IS  - 1029-2470 (Linking)
VI  - 39
IP  - 11
DP  - 2005 Nov
TI  - Effect of resistance exercise and carbohydrate ingestion on oxidative stress.
PG  - 1219-24
AB  - Some research studies have produced data indicating that resistance exercise 
      induces oxidative stress, despite minimal increases in VO(2). These studies have 
      primarily relied on oxidative stress markers with low sensitivity and debatable 
      reliability. However, F(2)-isoprostanes as measured by gas chromatography mass 
      spectrometry are considered to be a reliable and precise indicator of oxidative 
      stress. Carbohydrate ingestion during exercise is associated with reduced levels 
      of stress hormones, which may influence oxidative stress and plasma antioxidant 
      potential. Therefore, the purpose of this study was to investigate the influence 
      of carbohydrate ingestion during resistance training on F(2)-isoprostanes and 
      plasma antioxidant potential. Thirty strength-trained subjects were randomized to 
      carbohydrate (CHO) or placebo (PLA) groups that lifted weights for 2 h. Subjects 
      received 10 ml kg(- 1) h(- 1) CHO (6%) or PLA beverages during the exercise. 
      Blood and vastus lateralis muscle biopsy samples were collected before and after 
      exercise and analyzed for cortisol as a marker of general stress, 
      F(2)-isoprostanes as a measure of oxidative stress, and ferric reducing ability 
      of plasma (FRAP) as a measure of antioxidant potential, and for muscle glycogen, 
      respectively. Decreases in muscle glycogen content did not differ between CHO and 
      PLA. Cortisol and FRAP increased significantly in CHO and PLA (P = 0.008 and 
      0.044, respectively), but the pattern of change was not different between groups. 
      F(2)-isoprostanes were unaffected by exercise. These results indicate that 
      exhaustive resistance exercise and carbohydrate ingestion have no effect on 
      oxidative stress or plasma antioxidant potential in trained subjects.
FAU - McAnulty, Steven R
AU  - McAnulty SR
AD  - Department of Health, Leisure and Exercise Science, Appalachian State University, 
      Boone, NC 28608, USA. mcanltysr@appstate.edu
FAU - McAnulty, Lisa S
AU  - McAnulty LS
FAU - Nieman, David C
AU  - Nieman DC
FAU - Morrow, Jason D
AU  - Morrow JD
FAU - Utter, Alan C
AU  - Utter AC
FAU - Dumke, Charles L
AU  - Dumke CL
LA  - eng
GR  - CA-77839/CA/NCI NIH HHS/United States
GR  - DK-48831/DK/NIDDK NIH HHS/United States
GR  - GM-15431/GM/NIGMS NIH HHS/United States
GR  - RR00095/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Free Radic Res
JT  - Free radical research
JID - 9423872
RN  - 0 (Antioxidants)
RN  - 0 (Carbohydrates)
RN  - 0 (F2-Isoprostanes)
RN  - 9005-79-2 (Glycogen)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adult
MH  - Antioxidants/chemistry
MH  - Biopsy
MH  - Carbohydrate Metabolism
MH  - Carbohydrates/chemistry
MH  - Chromatography, Gas
MH  - *Exercise
MH  - F2-Isoprostanes/chemistry
MH  - Glycogen/metabolism
MH  - Humans
MH  - Hydrocortisone/metabolism
MH  - Lipid Peroxidation
MH  - Male
MH  - Mass Spectrometry
MH  - Muscle, Skeletal/metabolism/pathology
MH  - Muscles/pathology
MH  - *Oxidative Stress
MH  - Sensitivity and Specificity
MH  - Stress, Mechanical
MH  - Time Factors
EDAT- 2005/11/22 09:00
MHDA- 2006/03/15 09:00
CRDT- 2005/11/22 09:00
PHST- 2005/11/22 09:00 [pubmed]
PHST- 2006/03/15 09:00 [medline]
PHST- 2005/11/22 09:00 [entrez]
AID - R108706N76250X03 [pii]
AID - 10.1080/10725760500317536 [doi]
PST - ppublish
SO  - Free Radic Res. 2005 Nov;39(11):1219-24. doi: 10.1080/10725760500317536.