PMID- 16298870
OWN - NLM
STAT- MEDLINE
DCOM- 20051222
LR  - 20191109
IS  - 0148-0545 (Print)
IS  - 0148-0545 (Linking)
VI  - 28
IP  - 4
DP  - 2005
TI  - Acute, subchronic, and mutagenicity studies with norbornene fluoroalcohol.
PG  - 379-95
AB  - The object of this study was to evaluate the toxicity of norbornene fluoroalcohol 
      (NBFOH), which is used as an intermediate in the production of fluorinated 
      monomers and polymers. NBFOH was evaluated for acute oral, dermal, and inhalation 
      toxicity, dermal sensitization using the Local Lymph Node Assay (LLNA), 
      mutagenesis by the Ames assay, and subchronic toxicity in a 4-week inhalation rat 
      study. NBFOH demonstrated slight acute toxicity in oral, dermal, and inhalation 
      studies. Approximate lethal doses of 3400 and > 5000 mg/kg for the oral and 
      dermal routes, respectively, and an approximate lethal concentration of 4300 
      mg/m(3) were determined. NBFOH demonstrated moderate skin irritation, was a 
      severe eye irritant, produced dermal sensitization, but did not cause bacterial 
      mutagenicity either in the presence or absence of S9 activation. Male and female 
      rats were exposed nose only to airborne NBFOH at levels of 0, 410, 1400, and 1500 
      mg/m(3), 6 h/day, 5 days/week for 4 weeks with clinical and histopathology 
      specimens collected 1 day after the final exposure. Due to the vapor pressure of 
      NBFOH, the 1500 mg/m(3) atmosphere was 27% aerosol and 73% vapor; the 1400 
      mg/m(3) atmosphere was 5% aerosol and 95% vapor, and the 410 mg/m(3) level was 
      only vapor. No test substance-related mortality or clinical signs of toxicity 
      were observed over the course of the study, and male rats demonstrated 
      significant weight loss and decreased food consumption at 1400 mg/m(3). Male rats 
      from the 1500 mg/m(3) group demonstrated an 11% increase in prothrombin time that 
      was significantly higher than the control value. Examination of fluoride in the 
      urine did not demonstrate a concentration-response relationship, with minimal 
      elevations observed in male rats at all exposure levels and sporadic increases in 
      females. Both male and female rats exposed to 1400 mg/m(3) or greater had 
      squamous metaplasia of the laryngeal mucosa and degeneration of the nasal 
      olfactory and respiratory mucosa. Based on the above findings, NBFOH demonstrates 
      the potential to produce allergic contact dermatitis, and subchronic inhalation 
      studies indicate a no-observed-adverse-effect-level (NOAEL) of 410 mg/m(3).
FAU - DeLorme, Michael P
AU  - DeLorme MP
AD  - E. I. DuPont de Nemours and Company, Haskell Laboratory for Health and 
      Environmental Sciences, Newark, Delaware 19714-0050, USA. 
      michael.p.delorme@usa.dupont.com
FAU - Ladics, Gregory S
AU  - Ladics GS
FAU - Donner, E Maria
AU  - Donner EM
FAU - Wagner, Valentine O 3rd
AU  - Wagner VO 3rd
FAU - Finlay, Carol
AU  - Finlay C
FAU - Frame, Steven R
AU  - Frame SR
FAU - Everds, Nancy E
AU  - Everds NE
FAU - Loveless, Scott E
AU  - Loveless SE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Drug Chem Toxicol
JT  - Drug and chemical toxicology
JID - 7801723
RN  - 0 (Fluorocarbons)
RN  - 0 (Norbornanes)
RN  - 0 (Propanols)
RN  - Q80VPU408O (Fluorides)
SB  - IM
MH  - Animals
MH  - Edema/chemically induced
MH  - Erythema/chemically induced
MH  - Eye Diseases/chemically induced
MH  - Female
MH  - Fluorides/urine
MH  - Fluorocarbons/*toxicity
MH  - Local Lymph Node Assay
MH  - Male
MH  - Mice
MH  - Mice, Inbred CBA
MH  - Mutagenicity Tests
MH  - No-Observed-Adverse-Effect Level
MH  - Norbornanes/*toxicity
MH  - Propanols/*toxicity
MH  - Prothrombin Time
MH  - Rabbits
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2005/11/22 09:00
MHDA- 2005/12/24 09:00
CRDT- 2005/11/22 09:00
PHST- 2005/11/22 09:00 [pubmed]
PHST- 2005/12/24 09:00 [medline]
PHST- 2005/11/22 09:00 [entrez]
AID - M5Q3X1613XT284V7 [pii]
AID - 10.1080/01480540500262680 [doi]
PST - ppublish
SO  - Drug Chem Toxicol. 2005;28(4):379-95. doi: 10.1080/01480540500262680.