PMID- 16303203
OWN - NLM
STAT- MEDLINE
DCOM- 20071004
LR  - 20161128
IS  - 0168-8227 (Print)
IS  - 0168-8227 (Linking)
VI  - 72
IP  - 2
DP  - 2006 May
TI  - Normative values of carotid artery intima-media thickness in healthy Korean 
      adults and estimation of macrovascular diseases relative risk using this data in 
      type 2 diabetes patients.
PG  - 183-9
AB  - The objectives of this study were to determine normative values of carotid 
      intima-media thickness (IMT) in healthy Korean subjects and to use these values 
      to estimate the relative risk of macrovascular diseases in patients with type 2 
      diabetes mellitus (T2DM). High-resolution B-mode ultrasonography was performed in 
      1,229 healthy subjects and 830 T2DM patients. Height, weight, blood pressure, 
      fasting plasma glucose, total cholesterol, triglyceride, HDL-cholesterol, 
      LDL-cholesterol, and fasting insulin level were measured. Subjects were 
      classified as healthy subjects; T2DM patients without ischemic heart disease 
      (IHD), stroke, and peripheral arterial occlusive diseases (PAOD); T2DM patients 
      with IHD, stroke, or PAOD. IMT was significantly increased as age increased. 
      Patients with T2DM had higher IMTs compared to healthy subjects. Independent risk 
      factors of IMT were age, systolic blood pressure, BMI for healthy subjects, and 
      age, duration of diabetes, LDL-cholesterol for T2DM subjects. According to 
      presence of increased IMT, the relative risks of IHD, stroke, and PAOD in 
      diabetic subjects, were 2.34 (CI; 1.32-4.14), 2.95 (CI; 1.46-5.54), and 3.64 (CI; 
      1.66-7.40), respectively. This study suggests normative values that can be used 
      as an index for carotid artery IMT of healthy Korean subjects, and that IMT data 
      reflects the risk of macrovascular diseases in T2DM.
FAU - Kim, Chul Sik
AU  - Kim CS
AD  - Department of Internal Medicine, Yonsei University College of Medicine, 146-92, 
      Dogok-dong, P.O. Box 135-720, Seoul, Republic of Korea.
FAU - Kim, Hyeong Jin
AU  - Kim HJ
FAU - Won, Young Jun
AU  - Won YJ
FAU - Kim, Dae Jung
AU  - Kim DJ
FAU - Kang, Eun Seok
AU  - Kang ES
FAU - Ahn, Chul Woo
AU  - Ahn CW
FAU - Cha, Bong Soo
AU  - Cha BS
FAU - Lim, Sung Kil
AU  - Lim SK
FAU - Kim, Kyung Rae
AU  - Kim KR
FAU - Lee, Hyun Chul
AU  - Lee HC
FAU - Huh, Kap Bum
AU  - Huh KB
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051121
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Arterial Occlusive Diseases/etiology
MH  - Cardiovascular Diseases/*etiology
MH  - Carotid Artery, Common/*anatomy & histology/diagnostic imaging
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/complications/diagnostic imaging/*pathology
MH  - Female
MH  - Humans
MH  - Korea
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/etiology
MH  - Peripheral Vascular Diseases/etiology
MH  - Reference Values
MH  - Risk Factors
MH  - Sex Factors
MH  - Stroke/etiology
MH  - Tunica Intima/*anatomy & histology/diagnostic imaging
MH  - Tunica Media/*anatomy & histology/diagnostic imaging
MH  - Ultrasonography
EDAT- 2005/11/24 09:00
MHDA- 2007/10/05 09:00
CRDT- 2005/11/24 09:00
PHST- 2005/08/26 00:00 [received]
PHST- 2005/10/12 00:00 [accepted]
PHST- 2005/11/24 09:00 [pubmed]
PHST- 2007/10/05 09:00 [medline]
PHST- 2005/11/24 09:00 [entrez]
AID - S0168-8227(05)00410-9 [pii]
AID - 10.1016/j.diabres.2005.10.011 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2006 May;72(2):183-9. doi: 
      10.1016/j.diabres.2005.10.011. Epub 2005 Nov 21.