PMID- 16303674
OWN - NLM
STAT- MEDLINE
DCOM- 20060302
LR  - 20111117
IS  - 0001-6489 (Print)
IS  - 0001-6489 (Linking)
VI  - 125
IP  - 12
DP  - 2005 Dec
TI  - Human leukocyte antigen-DQB1 and -DRB1 associations in patients with idiopathic 
      sudden sensorineural hearing loss from a defined population of Northwest Spain.
PG  - 1277-82
AB  - CONCLUSION: The results of this study support the assertion that Southern 
      European individuals have a genetically mediated predisposition to develop 
      idiopathic sudden sensorineural hearing loss (SNHL). OBJECTIVE: To assess the 
      influence of human leukocyte antigen (HLA)-DQB1 and -DRB1 alleles on the 
      susceptibility to and the severity of idiopathic sudden SNHL. MATERIAL AND 
      METHODS: A prospective study of patients diagnosed with idiopathic sudden SNHL 
      between October 2000 and September 2002 was conducted. Patients were included in 
      the study if they were diagnosed with idiopathic sudden SNHL within 1 week after 
      the onset of deafness symptoms and had been followed for at least 12 months. 
      HLA-DQB1 and -DRB1 typing was performed from DNA using molecular-based methods on 
      patients and ethnically matched healthy controls. RESULTS: Thirty-three patients 
      fulfilled the inclusion criteria. No significant differences in HLA-DQB1 
      phenotype frequencies were found between patients and controls (n = 145). 
      Carriage of HLA-DRB1*0403 was significantly increased in the whole group of 
      patients compared with controls (OR = 11.97; 95% CI 1.99-91.60; p = 0.002; 
      p(corr) = 0.04). In patients without auditory improvement the frequency of the 
      HLA-DRB1*04 phenotype was significantly increased compared with healthy controls 
      (OR = 6.57; 95% CI 1.62-26.70; p = 0.003; p(corr) = 0.04).
FAU - Amor-Dorado, Juan C
AU  - Amor-Dorado JC
AD  - Division of Otolaryngology, Hospital Xeral-Calde, Lugo, Spain.
FAU - Paco, Laura
AU  - Paco L
FAU - Martin, Javier
AU  - Martin J
FAU - Lopez-Nevot, Miguel A
AU  - Lopez-Nevot MA
FAU - Gonzalez-Gay, Miguel A
AU  - Gonzalez-Gay MA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Female
MH  - Gene Expression Regulation
MH  - *Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/analysis/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/analysis/*genetics
MH  - HLA-DRB1 Chains
MH  - Hearing Loss, Sensorineural/diagnosis/epidemiology/*genetics
MH  - Hearing Loss, Sudden/diagnosis/epidemiology/*genetics
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Phenotype
MH  - Probability
MH  - Prospective Studies
MH  - Reference Values
MH  - Sensitivity and Specificity
MH  - Sex Distribution
MH  - Spain/epidemiology
EDAT- 2005/11/24 09:00
MHDA- 2006/03/03 09:00
CRDT- 2005/11/24 09:00
PHST- 2005/11/24 09:00 [pubmed]
PHST- 2006/03/03 09:00 [medline]
PHST- 2005/11/24 09:00 [entrez]
AID - V37H25626448R093 [pii]
AID - 10.1080/00016480510012228 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2005 Dec;125(12):1277-82. doi: 10.1080/00016480510012228.