PMID- 16304684
OWN - NLM
STAT- MEDLINE
DCOM- 20060314
LR  - 20061115
IS  - 0021-9967 (Print)
IS  - 0021-9967 (Linking)
VI  - 494
IP  - 1
DP  - 2006 Jan 1
TI  - Afferent projections to the pontine micturition center in the cat.
PG  - 36-53
AB  - The pontine micturition center (PMC) or Barrington's nucleus controls micturition 
      by way of its descending projections to the sacral spinal cord. However, little 
      is known about the afferents to the PMC that control its function and may be 
      responsible for dysfunction in patients with urge-incontinence and overactive 
      bladder. In five female cats, wheatgerm agglutinin-conjugated horseradish 
      peroxidase (WGA-HRP) injections were made in the PMC and adjoining dorsolateral 
      pontine tegmentum. Retrogradely labeled neurons were found in a large area, 
      including the medullary and pontine medial and lateral tegmental field; 
      dorsomedial, lateral, and ventrolateral periaqueductal gray matter (PAG); 
      posterior hypothalamus; medial preoptic area (MPO); bed nucleus of the stria 
      terminalis; central nucleus of the amygdala; and infralimbic, prelimbic, and 
      insular cortices. To verify whether these areas indeed project specifically to 
      the PMC or perhaps only to adjacent structures in the pontine tegmentum, in 67 
      cats (3)H-leucine or WGA-HRP injections were made in each of these regions. Five 
      cell groups appeared to have direct connections to the PMC, the ventromedial 
      pontomedullary tegmental field, the ventrolateral and dorsomedial PAG, the MPO, 
      and the posterior hypothalamus. The possible functions of these projections are 
      discussed. These results indicate that all other parts of the brain that 
      influence micturition have no direct connection with the PMC.
FAU - Kuipers, Rutger
AU  - Kuipers R
AD  - Department of Anatomy and Embryology, University Medical Center Groningen, The 
      Netherlands.
FAU - Mouton, Leonora J
AU  - Mouton LJ
FAU - Holstege, Gert
AU  - Holstege G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
RN  - 0 (Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate)
SB  - IM
MH  - Afferent Pathways/*cytology/metabolism
MH  - Animals
MH  - *Brain Mapping
MH  - Cats
MH  - Female
MH  - Models, Anatomic
MH  - Neurons/*cytology/metabolism
MH  - Pons/*cytology/metabolism
MH  - Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate/metabolism
EDAT- 2005/11/24 09:00
MHDA- 2006/03/15 09:00
CRDT- 2005/11/24 09:00
PHST- 2005/11/24 09:00 [pubmed]
PHST- 2006/03/15 09:00 [medline]
PHST- 2005/11/24 09:00 [entrez]
AID - 10.1002/cne.20775 [doi]
PST - ppublish
SO  - J Comp Neurol. 2006 Jan 1;494(1):36-53. doi: 10.1002/cne.20775.