PMID- 16304818
OWN - NLM
STAT- MEDLINE
DCOM- 20051214
LR  - 20110726
IS  - 0301-4894 (Print)
IS  - 0301-4894 (Linking)
VI  - 106
IP  - 11
DP  - 2005 Nov
TI  - [Medical applications of nanotechnology: polymeric micelles for drug delivery].
PG  - 700-5
AB  - Recently, medical applications of nanotechnology have received much attention. 
      Among them, drug delivery systems (DDSs) are expected to be the leading 
      technology in diagnostic and therapeutic medicine. An increasing number of DDSs 
      have been approved for clinical use or are currently being studied in clinical 
      trials. Polymeric micelles, self-assemblies of block copolymers, are one of the 
      most refined and promising modalities of DDSs, since the critical parameters such 
      as size, drug loading, and release can be controlled by engineering the 
      constituent block copolymers. It has been demonstrated that polymeric micelles 
      show unique disposition characteristics in the body suitable for drug targeting 
      (e.g., prolonged blood circulation and significant tumor accumulation). Also, 
      recent advances in polymer synthesis have allowed the development of polymeric 
      micelles with integrated smart functions such as environmental sensitivity and 
      targetability. Thus polymeric micelles might have great potential for 
      nanotechnology-based DDSs for clinical use.
FAU - Nishiyama, Nobuhiro
AU  - Nishiyama N
AD  - Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, 
      The University of Tokyo, Japan.
FAU - Kataoka, Kazunori
AU  - Kataoka K
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Geka Gakkai Zasshi
JT  - Nihon Geka Gakkai zasshi
JID - 0405405
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Micelles)
RN  - 0 (Polymers)
SB  - IM
MH  - Antineoplastic Agents/administration & dosage
MH  - *Drug Delivery Systems/trends
MH  - Humans
MH  - Micelles
MH  - *Nanotechnology
MH  - Polymers/administration & dosage
EDAT- 2005/11/25 09:00
MHDA- 2005/12/15 09:00
CRDT- 2005/11/25 09:00
PHST- 2005/11/25 09:00 [pubmed]
PHST- 2005/12/15 09:00 [medline]
PHST- 2005/11/25 09:00 [entrez]
PST - ppublish
SO  - Nihon Geka Gakkai Zasshi. 2005 Nov;106(11):700-5.