PMID- 16305070
OWN - NLM
STAT- MEDLINE
DCOM- 20051228
LR  - 20171116
IS  - 1479-1641 (Print)
IS  - 1479-1641 (Linking)
VI  - 2
IP  - 1
DP  - 2005 Feb
TI  - Metabolic syndrome-mediated inflammation following elective percutaneous coronary 
      intervention.
PG  - 31-6
AB  - There are few data concerning the relationship between diabetes mellitus, the 
      metabolic syndrome and inflammation following elective percutaneous coronary 
      intervention (PCI). The purpose of this study was to assess basal and peak levels 
      of candidate cytokines in 40 patients undergoing elective PCI. Patients were 
      categorised as having diabetes mellitus, the metabolic syndrome, or neither. 
      Patients with the metabolic syndrome exhibited significantly greater levels of 
      tumour necrosis factor-alpha over the study period, although this was unrelated 
      to PCI. There was a trend for increased levels of interleukin-6 following PCI, 
      primarily among patients with metabolic syndrome. Basal levels of monocyte 
      chemoattractant protein-1 (MCP-1) were not different among study groups; however, 
      the metabolic syndrome cohort had a trend towards increased circulating levels of 
      MCP-1 after PCI. In this patient population, the metabolic syndrome correlates 
      with a heightened inflammatory response following elective PCI.
FAU - Marso, Steven P
AU  - Marso SP
AD  - Mid America Heart Institute, Saint Luke's Hospital, Kansas City, Missouri 64111, 
      USA. smarso@saint-lukes.org
FAU - Murphy, Joseph W
AU  - Murphy JW
FAU - House, John A
AU  - House JA
FAU - Safley, David M
AU  - Safley DM
FAU - Harris, William S
AU  - Harris WS
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Diab Vasc Dis Res
JT  - Diabetes & vascular disease research
JID - 101234011
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Aged
MH  - Angioplasty, Balloon, Coronary/*adverse effects
MH  - Chemokine CCL2/blood
MH  - Diabetes Mellitus, Type 2/blood/complications/*therapy
MH  - Elective Surgical Procedures/adverse effects
MH  - Female
MH  - Humans
MH  - Inflammation/*etiology
MH  - Interleukin-6/blood
MH  - Male
MH  - Metabolic Syndrome/blood/etiology/*therapy
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prospective Studies
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/analysis
EDAT- 2005/11/25 09:00
MHDA- 2005/12/29 09:00
CRDT- 2005/11/25 09:00
PHST- 2005/11/25 09:00 [pubmed]
PHST- 2005/12/29 09:00 [medline]
PHST- 2005/11/25 09:00 [entrez]
AID - 10.3132/dvdr.2005.003 [doi]
PST - ppublish
SO  - Diab Vasc Dis Res. 2005 Feb;2(1):31-6. doi: 10.3132/dvdr.2005.003.