PMID- 16305803
OWN - NLM
STAT- MEDLINE
DCOM- 20060406
LR  - 20181201
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 78
IP  - 17
DP  - 2006 Mar 20
TI  - MDOC and atorvastatin have potential antiinflammatory effects in vascular 
      endothelium of apoE-/- mouse model of atherosclerosis.
PG  - 1983-9
AB  - Members of the immunoglobulin superfamily of endothelial adhesion molecules, 
      vascular cell adhesion molecule (VCAM-1) and intercellular cell adhesion molecule 
      (ICAM- 1), strongly participate in leukocyte adhesion to the endothelium and play 
      an important role in all stages of atherogenesis. The aim of this study was to 
      detect and quantify the changes of endothelial expression of VCAM-1, and ICAM-1 
      in the vessel wall after the short-term administration of simvastatin, 
      atorvastatin, and micro dispersed derivatives of oxidised cellulose (MDOC) in 
      apolipoprotein-E-deficient (apoE(-/-)) mice atherosclerotic model. Hyperlipidemic 
      apoE(-/-) mice (n = 32) received normal chow diet or diet containing simvastatin 
      or atorvastatin 10 mg/kg/day or MDOC 50 mg/kg/day. Total cholesterol, VLDL, LDL, 
      HDL and TAG were measured and the endothelial expression of VCAM-1 and ICAM-1 was 
      visualized and quantified by means of immunohistochemistry and stereology, 
      respectively. Total cholesterol levels was insignificantly lowered only in MDOC 
      treated mice but not in mice treated with statins. ICAM-1 endothelial expression 
      was not affected by neither simvastatin nor MDOC treatment. However, significant 
      diminution of VCAM-1 endothelial expression was observed in both atorvastatin and 
      MDOC treated mice. These results provide new information of potential 
      hypolipidemic substance MDOC and its potential anti-inflammatory effects. 
      Furthermore, we have confirmed anti-inflammatory effects of atorvastatin 
      independent of plasma cholesterol lowering. Thus, the results of this study show 
      potential benefit of both MDOC and atorvastatin treatment in apoE(-/-) mouse 
      model of atherosclerosis suggesting their possible combination might be of 
      interest.
FAU - Nachtigal, Petr
AU  - Nachtigal P
AD  - Department of Biological and Medical Sciences, Faculty of Pharmacy, Charles 
      University Hradec Kralove, Heyrovskeho 1203, Hradec Kralove, 50005 Czech 
      Republic. nachti@faf.cuni.cz
FAU - Pospisilova, Nada
AU  - Pospisilova N
FAU - Pospechova, Katerina
AU  - Pospechova K
FAU - Jamborova, Gabriela
AU  - Jamborova G
FAU - Kopecky, Martin
AU  - Kopecky M
FAU - Jaynes, Robert
AU  - Jaynes R
FAU - Briestensky, Jiri
AU  - Briestensky J
FAU - Santar, Ivan
AU  - Santar I
FAU - Smahelova, Alena
AU  - Smahelova A
FAU - Solichova, Dagmar
AU  - Solichova D
FAU - Zdansky, Petr
AU  - Zdansky P
FAU - Semecky, Vladimir
AU  - Semecky V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051121
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Apolipoproteins E)
RN  - 0 (Cellulose, Oxidized)
RN  - 0 (Heptanoic Acids)
RN  - 0 (Lipoproteins)
RN  - 0 (Pyrroles)
RN  - 0 (Triglycerides)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - A0JWA85V8F (Atorvastatin)
RN  - AGG2FN16EV (Simvastatin)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology/therapeutic use
MH  - Apolipoproteins E/*deficiency/genetics
MH  - *Atherosclerosis/drug therapy
MH  - Atorvastatin
MH  - Cellulose, Oxidized/*pharmacology/therapeutic use
MH  - Diet
MH  - Disease Models, Animal
MH  - Endothelium, Vascular/*drug effects/metabolism/pathology
MH  - Heptanoic Acids/*pharmacology/therapeutic use
MH  - Hyperlipidemias/drug therapy
MH  - Intercellular Adhesion Molecule-1/metabolism
MH  - Lipoproteins/blood
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Pyrroles/*pharmacology/therapeutic use
MH  - Simvastatin/pharmacology
MH  - Triglycerides/blood
MH  - Vascular Cell Adhesion Molecule-1/metabolism
EDAT- 2005/11/25 09:00
MHDA- 2006/04/07 09:00
CRDT- 2005/11/25 09:00
PHST- 2005/02/01 00:00 [received]
PHST- 2005/08/31 00:00 [accepted]
PHST- 2005/11/25 09:00 [pubmed]
PHST- 2006/04/07 09:00 [medline]
PHST- 2005/11/25 09:00 [entrez]
AID - S0024-3205(05)01051-9 [pii]
AID - 10.1016/j.lfs.2005.08.041 [doi]
PST - ppublish
SO  - Life Sci. 2006 Mar 20;78(17):1983-9. doi: 10.1016/j.lfs.2005.08.041. Epub 2005 
      Nov 21.