PMID- 16305958
OWN - NLM
STAT- MEDLINE
DCOM- 20070629
LR  - 20181203
IS  - 1000-2588 (Print)
IS  - 1000-2588 (Linking)
VI  - 25
IP  - 11
DP  - 2005 Nov
TI  - [Bone defect repair with a new tissue-engineered bone carrying bone morphogenetic 
      protein in rabbits].
PG  - 1369-74
AB  - OBJECTIVE: To construct a new tissue-engineered bone with poly (D, 
      L-lactide-co-glycolide) (PLGA), bone morphogenetic protein (BMP) and bone 
      marrow-derived stem cells (BMSCs) and observe its effect in repairing segmental 
      bone defects. METHODS: A 15-mm bone defect in the right radius was induced in New 
      Zealand white rabbits, and the models were randomized into three groups to 
      receive implantation of the tissue-engineered bone grafts constructed with PLGA 
      carrying 5 mg BMP and about 1 x 10(6) BMSCs (experimental group), grafts of PLGA 
      with about 1 x 10(6) BMSCs (control group), or grafts of exclusive PLGA (blank 
      control group), respectively. The osteogenesis in the bone defect after the 
      implantation on was evaluated X-ray films, and the histological changes of the 
      tissues sampled from the bone defect 4, 8, and 12 weeks after operation were 
      observed and new bone formation was measured by image analysis. RESULTS: The bone 
      defect was completely repaired in the experimental group 12 weeks after the 
      implantation, showing the best results among the 3 groups. The bone defects in 
      the blank control group was filled with only fibrous and connective tissues at 12 
      weeks. CONCLUSION: This tissue-engineered bone constructed with PLGA, BMP and 
      BMSCs possesses good ability in repairing segmental bone defect.
FAU - Hu, Ji-jie
AU  - Hu JJ
AD  - Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical 
      University, Guangzhou 510515, China. hjj0610@163.com
FAU - Jin, Dan
AU  - Jin D
FAU - Quan, Da-ping
AU  - Quan DP
FAU - Zhong, Shi-zhen
AU  - Zhong SZ
FAU - Chen, Jiong-hao
AU  - Chen JH
FAU - Wei, Kuan-Hai
AU  - Wei KH
FAU - Zhao, Jie
AU  - Zhao J
FAU - Pei, Guo-xian
AU  - Pei GX
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Di Yi Jun Yi Da Xue Xue Bao
JT  - Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA
JID - 9426110
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 0 (Bone Substitutes)
RN  - 0 (Polymers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells/cytology
MH  - *Bone Morphogenetic Proteins/genetics/therapeutic use
MH  - Bone Regeneration/drug effects
MH  - Bone Substitutes
MH  - Cells, Cultured
MH  - Female
MH  - Implants, Experimental
MH  - Lactic Acid/*therapeutic use
MH  - Male
MH  - Mesenchymal Stem Cells/*cytology
MH  - Polyglycolic Acid/*therapeutic use
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/*therapeutic use
MH  - Rabbits
MH  - Radius Fractures/*surgery
MH  - Random Allocation
MH  - *Tissue Engineering
EDAT- 2005/11/25 09:00
MHDA- 2007/06/30 09:00
CRDT- 2005/11/25 09:00
PHST- 2005/11/25 09:00 [pubmed]
PHST- 2007/06/30 09:00 [medline]
PHST- 2005/11/25 09:00 [entrez]
PST - ppublish
SO  - Di Yi Jun Yi Da Xue Xue Bao. 2005 Nov;25(11):1369-74.