PMID- 16306505
OWN - NLM
STAT- MEDLINE
DCOM- 20060113
LR  - 20181113
IS  - 1473-0480 (Electronic)
IS  - 0306-3674 (Print)
IS  - 0306-3674 (Linking)
VI  - 39
IP  - 12
DP  - 2005 Dec
TI  - Effects of dietary carbohydrate on delayed onset muscle soreness and reactive 
      oxygen species after contraction induced muscle damage.
PG  - 948-53
AB  - BACKGROUND: Delayed onset muscle soreness (DOMS) occurs after unaccustomed 
      exercise and has been suggested to be attributable to reactive oxygen species 
      (ROS). Previous studies have shown increased ROS after lengthening contractions, 
      attributable to invading phagocytes. Plasma glucose is a vital fuel for 
      phagocytes, therefore carbohydrate (CHO) status before exercise may influence ROS 
      production and DOMS. OBJECTIVE: To examine the effect of pre-exercise CHO status 
      on DOMS, ROS production, and muscle function after contraction induced muscle 
      damage. METHOD: Twelve subjects performed two downhill runs, one after a high CHO 
      diet and one after a low CHO diet. Blood samples were drawn for analysis of 
      malondialdehyde, total glutathione, creatine kinase, non-esterified fatty acids, 
      lactate, glucose, and leucocytes. DOMS and muscle function were assessed daily. 
      RESULTS: The high CHO diet resulted in higher respiratory exchange ratio and 
      lactate concentrations than the low CHO diet before exercise. The low CHO diet 
      resulted in higher non-esterified fatty acid concentrations before exercise. DOMS 
      developed after exercise and remained for up to 96 hours, after both diets. A 
      biphasic response in creatine kinase occurred after both diets at 24 and 96 hours 
      after exercise. Malondialdehyde had increased 72 hours after exercise after both 
      diets, and muscle function was attenuated up to this time. CONCLUSIONS: Downhill 
      running resulted in increased ROS production and ratings of DOMS and secondary 
      increases in muscle damage. CHO status before exercise had no effect.
FAU - Close, G L
AU  - Close GL
AD  - Liverpool John Moores University, Liverpool, UK. gclose@liv.ac.uk
FAU - Ashton, T
AU  - Ashton T
FAU - Cable, T
AU  - Cable T
FAU - Doran, D
AU  - Doran D
FAU - Noyes, C
AU  - Noyes C
FAU - McArdle, F
AU  - McArdle F
FAU - MacLaren, D P M
AU  - MacLaren DP
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Sports Med
JT  - British journal of sports medicine
JID - 0432520
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Reactive Oxygen Species)
RN  - EC 2.7.3.2 (Creatine Kinase)
SB  - IM
MH  - Adult
MH  - Carbohydrate Metabolism/physiology
MH  - Creatine Kinase/analysis
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Exercise Test/methods
MH  - Humans
MH  - Leukocyte Count
MH  - Male
MH  - Muscle Contraction/*physiology
MH  - Muscle, Skeletal/*pathology/physiopathology
MH  - Oxygen Consumption/physiology
MH  - Pain/etiology
MH  - Reactive Oxygen Species/*metabolism
MH  - Running/*physiology
PMC - PMC1725093
EDAT- 2005/11/25 09:00
MHDA- 2006/01/18 09:00
PMCR- 2008/12/01
CRDT- 2005/11/25 09:00
PHST- 2005/11/25 09:00 [pubmed]
PHST- 2006/01/18 09:00 [medline]
PHST- 2005/11/25 09:00 [entrez]
PHST- 2008/12/01 00:00 [pmc-release]
AID - 39/12/948 [pii]
AID - 10.1136/bjsm.2005.019844 [doi]
PST - ppublish
SO  - Br J Sports Med. 2005 Dec;39(12):948-53. doi: 10.1136/bjsm.2005.019844.