PMID- 16306765
OWN - NLM
STAT- MEDLINE
DCOM- 20060426
LR  - 20221207
IS  - 1078-0998 (Print)
IS  - 1078-0998 (Linking)
VI  - 11
IP  - 12
DP  - 2005 Dec
TI  - Association between IL-18 gene promoter polymorphisms and inflammatory bowel 
      disease in a Japanese population.
PG  - 1038-43
AB  - BACKGROUND: Interleukin-18 (IL-18) is a pleiotropic cytokine that induces the 
      production of interferon (IFN)-gamma and also to regulate Th2 cytokines. 
      Recently, association studies between IL-18 gene promoter polymorphisms and 
      several Th1- or Th2-mediated inflammatory diseases were reported. In inflammatory 
      bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), 
      recent evidence suggests that IL-18 is involved in the pathogenesis. METHODS: 
      Using DNA direct sequencing, we investigated IL-18 gene promoter polymorphisms at 
      -607C/A and -137G/C. Allele, genotype, and haplotype frequencies were determined 
      in 210 Japanese patients with UC, 205 patients with CD, and 212 controls. 
      RESULTS: In UC, the -137C allele frequency was significantly higher in the 
      proctitis-type patients than in controls (Pc = 0.0068). The -137 genotype 
      frequency was also significantly different in the proctitis-type patients than in 
      controls (Pc = 0.032). No other allele and genotype frequencies were 
      significantly associated with UC after Bonferroni correction. Furthermore, the 
      frequency of haplotype 2 (-607A, -137C), which had a lower promoter activity and 
      IFN-gamma mRNA level than the other haplotypes as previously reported, was 
      significantly higher in the proctitis-type patients than in controls (Pc = 0.01). 
      In CD, we could not find any significant differences. CONCLUSIONS: IL-18 gene 
      promoter polymorphisms may not be associated with disease susceptibility but 
      related to the extent of disease in UC.
FAU - Takagawa, T
AU  - Takagawa T
AD  - Division of Lower Gastroenterology, Department of Internal Medicine, Hyogo 
      College of Medicine, Nishinomiya, Japan.
FAU - Tamura, K
AU  - Tamura K
FAU - Takeda, N
AU  - Takeda N
FAU - Tomita, T
AU  - Tomita T
FAU - Ohda, Y
AU  - Ohda Y
FAU - Fukunaga, K
AU  - Fukunaga K
FAU - Hida, N
AU  - Hida N
FAU - Ohnishi, K
AU  - Ohnishi K
FAU - Hori, K
AU  - Hori K
FAU - Kosaka, T
AU  - Kosaka T
FAU - Fukuda, Y
AU  - Fukuda Y
FAU - Ikeuchi, H
AU  - Ikeuchi H
FAU - Yamamura, T
AU  - Yamamura T
FAU - Miwa, H
AU  - Miwa H
FAU - Matsumoto, T
AU  - Matsumoto T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Inflamm Bowel Dis
JT  - Inflammatory bowel diseases
JID - 9508162
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Asian People
MH  - Colitis, Ulcerative/*genetics
MH  - Crohn Disease/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - Promoter Regions, Genetic/*genetics
EDAT- 2005/11/25 09:00
MHDA- 2006/04/28 09:00
CRDT- 2005/11/25 09:00
PHST- 2005/11/25 09:00 [pubmed]
PHST- 2006/04/28 09:00 [medline]
PHST- 2005/11/25 09:00 [entrez]
AID - 00054725-200512000-00002 [pii]
AID - 10.1097/01.mib.0000182868.67025.b9 [doi]
PST - ppublish
SO  - Inflamm Bowel Dis. 2005 Dec;11(12):1038-43. doi: 
      10.1097/01.mib.0000182868.67025.b9.