PMID- 16307851
OWN - NLM
STAT- MEDLINE
DCOM- 20060413
LR  - 20060220
IS  - 0378-4274 (Print)
IS  - 0378-4274 (Linking)
VI  - 162
IP  - 1
DP  - 2006 Mar 15
TI  - Interactions between dendritic cells and epithelial cells in allergic disease.
PG  - 71-82
AB  - Dendritic cells (DCs) play a crucial role in the sensitisation process. Upon 
      encounter with an allergen, DCs require interactions with other cells and factors 
      for triggering a primary or secondary immune response. Epithelial cells (ECs) 
      express features of accessory cells, such as expression of HLA-DR, co-stimulatory 
      molecules, functional FcgammaR, molecules of the antigen-processing machinery, 
      and display an ability to internalise antigen. These features may authorize them 
      to function as immunomodulators (e.g. amplification of memory T cells during 
      secondary immune responses). ECs may increase chemokine (e.g. CCL20) secretion 
      thereby attracting DCs. Epithelial human TSLP activates DC, which allow them to 
      prime naive T cells for the production of pro-inflammatory cytokines, while 
      down-regulating IFN-gamma and IL-10. ECs may also influence the local 
      polarization of types l and 2 antigen-presenting cells via PGE(2) by impairing 
      the ability of maturing DC to produce bioactive IL-12 p70. PGE(2) is synergistic 
      with IL-1beta and TNF-alpha in the induction of functional and phenotypic 
      maturation of DC and induce IL12 p40 production. Sensitisation via the 
      respiratory route may be Th(2) skewed, possibly because the antigen recognition 
      by DC occurs in an environment rich of airway EC-product such as PGE(2).
FAU - Roggen, Erwin L
AU  - Roggen EL
AD  - Department of Protein Screening, Novozymes AS, Smoermosevej 11, 2880 Bagsvaerd, 
      Denmark. elro@novozymes.com
FAU - Lindstedt, Malin
AU  - Lindstedt M
FAU - Borrebaeck, Carl
AU  - Borrebaeck C
FAU - Verheyen, Geert R
AU  - Verheyen GR
LA  - eng
PT  - Journal Article
DEP - 20051122
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Cytokines)
SB  - IM
MH  - Cell Line
MH  - Cytokines/immunology
MH  - Dendritic Cells/*immunology
MH  - Epithelial Cells/*immunology
MH  - Humans
MH  - Hypersensitivity/*immunology
EDAT- 2005/11/26 09:00
MHDA- 2006/04/14 09:00
CRDT- 2005/11/26 09:00
PHST- 2005/11/26 09:00 [pubmed]
PHST- 2006/04/14 09:00 [medline]
PHST- 2005/11/26 09:00 [entrez]
AID - S0378-4274(05)00352-8 [pii]
AID - 10.1016/j.toxlet.2005.10.013 [doi]
PST - ppublish
SO  - Toxicol Lett. 2006 Mar 15;162(1):71-82. doi: 10.1016/j.toxlet.2005.10.013. Epub 
      2005 Nov 22.