PMID- 16308496
OWN - NLM
STAT- MEDLINE
DCOM- 20060124
LR  - 20190819
IS  - 1346-9843 (Print)
IS  - 1346-9843 (Linking)
VI  - 69
IP  - 12
DP  - 2005 Dec
TI  - Elevated monocyte chemoattractant protein-1 serum levels in patients at risk for 
      coronary artery disease.
PG  - 1484-9
AB  - BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) is involved in the 
      recruitment of monocytes into the arterial vessel wall as one of the major events 
      leading to atherosclerotic vascular diseases, such as coronary artery disease 
      (CAD). METHODS AND RESULTS: The study group comprised 263 volunteers aged between 
      18 and 85 years who were admitted to hospital or clinic for scheduled invasive 
      and non-invasive diagnostic procedures. MCP-1 serum levels were determined using 
      a sandwich-enzyme-linked immunosorbent assay. In each patient, the coronary risk 
      factors (CRF), such as hypertension, high cholesterol, diabetes mellitus, 
      obesity, positive family history, and smoking were evaluated. Low-density 
      lipoprotein-cholesterol, lipoprotein(a), and hemoglobinA1C levels were 
      determined. Patients with CAD proven by angiography had significantly increased 
      MCP-1 levels. In patients without CAD, the increase in MCP-1 depended on the 
      number of CRF. As a marker for endothelial activation the soluble adhesion 
      molecules, soluble intercellular adhesion molecule and soluble E-selectin were 
      measured and both markers were significantly elevated in patients with CAD or 
      multiple CRF when compared with patients without CRF. Although this is not a 
      direct proof, endothelial activation could contribute to elevated MCP-1 levels in 
      atherosclerosis. CONCLUSION: Elevated MCP-1 serum levels could serve as a direct 
      marker of the inflammatory activity in patients at risk for coronary artery and 
      other atherosclerotic vascular diseases.
FAU - Martinovic, Ivo
AU  - Martinovic I
AD  - Department of Heart Surgery, Philipps-University Marburg Medical Center, Mainz, 
      Germany.
FAU - Abegunewardene, Nico
AU  - Abegunewardene N
FAU - Seul, Marco
AU  - Seul M
FAU - Vosseler, Markus
AU  - Vosseler M
FAU - Horstick, Georg
AU  - Horstick G
FAU - Buerke, Michael
AU  - Buerke M
FAU - Darius, Harald
AU  - Darius H
FAU - Lindemann, Stephan
AU  - Lindemann S
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Atherosclerosis/blood/diagnosis
MH  - Biomarkers/blood
MH  - Chemokine CCL2/*blood
MH  - Coronary Angiography
MH  - Coronary Artery Disease/blood/*diagnosis
MH  - Endothelium, Vascular/metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
EDAT- 2005/11/26 09:00
MHDA- 2006/01/25 09:00
CRDT- 2005/11/26 09:00
PHST- 2005/11/26 09:00 [pubmed]
PHST- 2006/01/25 09:00 [medline]
PHST- 2005/11/26 09:00 [entrez]
AID - JST.JSTAGE/circj/69.1484 [pii]
AID - 10.1253/circj.69.1484 [doi]
PST - ppublish
SO  - Circ J. 2005 Dec;69(12):1484-9. doi: 10.1253/circj.69.1484.