PMID- 16309200
OWN - NLM
STAT- MEDLINE
DCOM- 20060105
LR  - 20061115
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 25
IP  - 6B
DP  - 2005 Nov-Dec
TI  - Aneuploidy of chromosome 8 and C-MYC amplification in individuals from northern 
      Brazil with gastric adenocarcinoma.
PG  - 4069-74
AB  - BACKGROUND: Gastric cancer is the third most frequent type of neoplasia. In 
      northern Brazil, the State of Para has a high incidence of this type of 
      neoplasia. Limited data are available so far on the genetic events involved in 
      this disease. MATERIALS AND METHODS: Dual-color fluorescence in situ 
      hybridization (FISH) for the C-MYC gene and chromosome 8 centromere was performed 
      in 11 gastric adenocarcinomas. RESULTS: All cases showed aneuploidy of chromosome 
      8 and C-MYC amplification, in both the diffuse and the intestinal 
      histopathological types of Lauren. No correlation was found between polysomy 8 
      and the histopathological characteristics of the tumors. C-MYC amplification, 
      like homogeneously-stained regions (HSRs) and double minutes (DMs), was observed 
      only in the intestinal-type. Translocation of C-MYC was observed only in the 
      diffuse-type. CONCLUSION: Chromosome 8 can be used as a marker in the diagnosis 
      of gastric adenocarcinoma. The C-MYC oncogene requires further studies in order 
      to verify if it is, when amplified, an etiological cause of transformation or a 
      consequence of the proliferation process.
FAU - Calcagno, Danielle Queiroz
AU  - Calcagno DQ
AD  - Human Cytogenetics and Toxicological Genetics Laboratory, Department of Biology, 
      Center of Biological Sciences, Federal University of Para, Belem, PA, Brazil.
FAU - Leal, Mariana Ferreira
AU  - Leal MF
FAU - Taken, Sylvia Satomi
AU  - Taken SS
FAU - Assumpcao, Paulo Pimentel
AU  - Assumpcao PP
FAU - Demachki, Samia
AU  - Demachki S
FAU - Smith, Marilia de Arruda Cardoso
AU  - Smith Mde A
FAU - Burbano, Rommel Rodriguez
AU  - Burbano RR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
EIN - Anticancer Res. 2006 Jan-Feb;26(1a):445
MH  - Adenocarcinoma/blood/*genetics
MH  - Adult
MH  - Alleles
MH  - *Aneuploidy
MH  - Brazil
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Gene Amplification
MH  - Gene Rearrangement
MH  - Genes, myc/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphocytes/ultrastructure
MH  - Male
MH  - Middle Aged
MH  - Stomach Neoplasms/blood/*genetics
MH  - Translocation, Genetic
EDAT- 2005/11/29 09:00
MHDA- 2006/01/06 09:00
CRDT- 2005/11/29 09:00
PHST- 2005/11/29 09:00 [pubmed]
PHST- 2006/01/06 09:00 [medline]
PHST- 2005/11/29 09:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 2005 Nov-Dec;25(6B):4069-74.