PMID- 16310763
OWN - NLM
STAT- MEDLINE
DCOM- 20060321
LR  - 20081121
IS  - 0012-1606 (Print)
IS  - 0012-1606 (Linking)
VI  - 289
IP  - 2
DP  - 2006 Jan 15
TI  - The bZip proteins CES-2 and ATF-2 alter the timing of transcription for a 
      cell-specific target gene in C. elegans.
PG  - 456-65
AB  - The Caenorhabditis elegans basic leucine zipper (bZip) protein CES-2 regulates 
      the transcription of different genes in different cells. Here, we show that CES-2 
      mediates its effects in one cell (the excretory duct cell) together with another 
      bZip protein, ATF-2. Both proteins influence transactivation of a target gene, 
      lin-48. Although lin-48 is required for both anatomical and physiological 
      features of the excretory duct cell, ces-2 and atf-2 mutants only exhibit 
      anatomical defects. We show that CES-2 and ATF-2 modify the temporal 
      transcription of lin-48, acting to initiate embryonic expression required for 
      normal excretory system development and anatomy. In contrast, CES-2 and ATF-2 do 
      not influence post-embryonic lin-48 expression. We provide evidence that CES-2 
      and ATF-2 can interact with each other, and that they cooperate to form a complex 
      on lin-48 regulatory sequences. Thus, the two bZip proteins function together as 
      one of several inputs that influence the spatial and temporal regulation of 
      lin-48.
FAU - Wang, Xiaodong
AU  - Wang X
AD  - Department of Molecular Genetics, Ohio State University, 938 Biological Sciences 
      Building, 484 West 12th Avenue, Columbus, 43210, USA.
FAU - Jia, Hongtao
AU  - Jia H
FAU - Chamberlin, Helen M
AU  - Chamberlin HM
LA  - eng
GR  - GM62336/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20051128
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (Activating Transcription Factor 2)
RN  - 0 (Basic-Leucine Zipper Transcription Factors)
RN  - 0 (CES-2 protein, C elegans)
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (Lin-48 protein, C elegans)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Activating Transcription Factor 2/*genetics/metabolism
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Base Sequence
MH  - Basic-Leucine Zipper Transcription Factors/*genetics/metabolism
MH  - Binding Sites
MH  - Caenorhabditis elegans/cytology/embryology/*genetics
MH  - Caenorhabditis elegans Proteins/*genetics/metabolism
MH  - Evolution, Molecular
MH  - Gene Expression Regulation
MH  - Gene Expression Regulation, Developmental
MH  - Larva/cytology/genetics/metabolism
MH  - Molecular Sequence Data
MH  - Species Specificity
MH  - Transcription Factors/genetics/metabolism
MH  - *Transcription, Genetic
MH  - Transcriptional Activation
MH  - Transgenes
EDAT- 2005/11/29 09:00
MHDA- 2006/03/22 09:00
CRDT- 2005/11/29 09:00
PHST- 2005/06/30 00:00 [received]
PHST- 2005/10/08 00:00 [revised]
PHST- 2005/10/18 00:00 [accepted]
PHST- 2005/11/29 09:00 [pubmed]
PHST- 2006/03/22 09:00 [medline]
PHST- 2005/11/29 09:00 [entrez]
AID - S0012-1606(05)00757-8 [pii]
AID - 10.1016/j.ydbio.2005.10.029 [doi]
PST - ppublish
SO  - Dev Biol. 2006 Jan 15;289(2):456-65. doi: 10.1016/j.ydbio.2005.10.029. Epub 2005 
      Nov 28.