PMID- 16311409
OWN - NLM
STAT- MEDLINE
DCOM- 20060124
LR  - 20181113
IS  - 1355-008X (Print)
IS  - 1355-008X (Linking)
VI  - 28
IP  - 1
DP  - 2005 Oct
TI  - Genetics and proteomics of pituitary tumors.
PG  - 43-7
AB  - Genetics and proteomics determine structure and function of normal tissues, and 
      the molecular alterations that underlie tumorigenesis result in changes in these 
      aspects of tissue biology in neoplasms. We review the known genetic alterations 
      in pituitary tumors. These include the oncogenic Gsalpha protein (GSP)-activating 
      mutations, and pituitary tumor-derived fibroblast growth factor receptor-4 
      (ptd-FGFR4), as well as tumor suppressor gene mutations associated with multiple 
      endocrine neoplasia type 1 (MEN1). Other candidates identified from expression 
      profiling include pituitary tumor-transforming gene (PTTG), GADD45, and bone 
      morphogenic protein (BMP)4. Proteomic changes in pituitary tumors include 
      classical alterations identified by immunohistochemistry as well as epigenetic 
      reductions in p27. The underlying mechanisms for dysregulated cell adhesive 
      molecules including cadherins and FGFRs are reviewed. The combined use of genetic 
      and proteomic approaches will enhance novel drug therapeutic development.
FAU - Asa, Sylvia L
AU  - Asa SL
AD  - Endocrine Oncology Site Group, Mount Sinai and Princess Margaret Hospitals, 
      University of Toronto, Toronto, Ontario, Canada. sylvia.asa@uhn.on.ca
FAU - Ezzat, Shereen
AU  - Ezzat S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Endocrine
JT  - Endocrine
JID - 9434444
RN  - 0 (GTP-Binding Protein alpha Subunits)
RN  - 9034-39-3 (Growth Hormone-Releasing Hormone)
RN  - EC 2.7.10.1 (FGFR4 protein, human)
RN  - EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 4)
SB  - IM
MH  - Adenoma/*genetics/*metabolism
MH  - GTP-Binding Protein alpha Subunits/biosynthesis/genetics
MH  - Gene Expression Profiling
MH  - Genes, Tumor Suppressor
MH  - Growth Hormone-Releasing Hormone/biosynthesis/genetics
MH  - Humans
MH  - Pituitary Neoplasms/*genetics/*metabolism
MH  - Proteomics
MH  - Receptor, Fibroblast Growth Factor, Type 4/biosynthesis/genetics
RF  - 49
EDAT- 2005/11/29 09:00
MHDA- 2006/01/25 09:00
CRDT- 2005/11/29 09:00
PHST- 2005/06/13 00:00 [received]
PHST- 2005/07/14 00:00 [accepted]
PHST- 2005/11/29 09:00 [pubmed]
PHST- 2006/01/25 09:00 [medline]
PHST- 2005/11/29 09:00 [entrez]
AID - ENDO:28:1:043 [pii]
AID - 10.1385/ENDO:28:1:043 [doi]
PST - ppublish
SO  - Endocrine. 2005 Oct;28(1):43-7. doi: 10.1385/ENDO:28:1:043.