PMID- 16312942
OWN - NLM
STAT- MEDLINE
DCOM- 20060126
LR  - 20221207
IS  - 1049-510X (Print)
IS  - 1049-510X (Linking)
VI  - 15
IP  - 4 Suppl 5
DP  - 2005 Autumn
TI  - Invasive group A streptococcal disease: race, hypotension, and immunogenetics.
PG  - S5-63-6
AB  - OBJECTIVE: To determine if there was an association between race and the 
      incidence of hypotension among patients hospitalized for invasive group A 
      streptococcal disease (IGASD). DESIGN: Data were obtained from a retrospective 
      cohort study of IGASD patients. The subjects were hospitalized throughout Florida 
      for IGASD between 1996 and 2000 (N=151). The exposure variable for the current 
      study was race (African Americans, Caucasians). The binary outcome was the 
      presence of hypotension within 48 hours of hospital admission. A sensitivity 
      analysis was performed to determine if a particular human leukocyte antigen (HLA) 
      class II haplotype (DRB1*1501/DQB1*0602) confounded the association between race 
      and the risk of hypotension. IGASD patients possessing this haplotype are less 
      likely to experience hypotension with multiple organ failure. RESULTS: We found 
      that Caucasians had three times the odds of developing hypotension than African 
      Americans (adjusted odds ratio=3.02, 95% confidence interval: 1.10-8.29, P=.03). 
      The sensitivity analysis revealed that the HLA class II haplotype 
      DRB1*1501/DQB1*0602 was most likely not a confounder. CONCLUSIONS: Caucasians 
      were significantly more likely than African Americans to develop the adverse 
      outcome of hypotension within 48 hours of being hospitalized for IGASD. This 
      excess risk is most likely not due to a particular host genetic factor, the HLA 
      class II haplotype DRB1*1501/DQB1*0602.
FAU - Mulla, Zuber D
AU  - Mulla ZD
AD  - Division of Epidemiology and Center for Infectious Diseases, University of Texas 
      School of Public Health at Houston, El Paso, Texas 79902, USA. 
      zuber.d.mulla@uth.tmc.edu
FAU - Gibbs, Shawn G
AU  - Gibbs SG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ethn Dis
JT  - Ethnicity & disease
JID - 9109034
SB  - IM
MH  - Black or African American/statistics & numerical data
MH  - Ethnicity
MH  - Female
MH  - Florida/epidemiology
MH  - Humans
MH  - Hypotension/complications/*ethnology/etiology
MH  - *Immunogenetics
MH  - Male
MH  - Retrospective Studies
MH  - Streptococcal Infections/complications/*ethnology/immunology/microbiology
MH  - Streptococcus pyogenes/*isolation & purification
MH  - White People/statistics & numerical data
EDAT- 2005/11/30 09:00
MHDA- 2006/01/27 09:00
CRDT- 2005/11/30 09:00
PHST- 2005/11/30 09:00 [pubmed]
PHST- 2006/01/27 09:00 [medline]
PHST- 2005/11/30 09:00 [entrez]
PST - ppublish
SO  - Ethn Dis. 2005 Autumn;15(4 Suppl 5):S5-63-6.