PMID- 163134
OWN - NLM
STAT- MEDLINE
DCOM- 19750509
LR  - 20190619
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 35
IP  - 2
DP  - 1975 Feb
TI  - The glycolytic enzyme activity of the human cervix uteri.
PG  - 469-74
AB  - The activity of the following enzymes was studied in normal, precancerous, and 
      malignant biopsies from the human cervix uteri: hexokinase (HK), 
      phosphofructokinase (PFK), pyruvate-kinase (PK), lactate dehydrogenase (LDH), and 
      glucose-6-phosphate dehydrogenase (G-6-PDH). In precancerous conditions, i.e., 
      dysplasia and carcinoma in situ without any signs of invasive carcinoma, only PK 
      showed moderate but significant activity increases. A rise in enzyme activity in 
      biopsies histologically classified as carcinoma in situ was found to signal the 
      presence of invasive carcinoma in other parts of the cervix. In invasive 
      carcinomas of the cervix, all the enzymes studied showed a two- to four-fold 
      increase (p less than 0.01) as compared to the normal cervix. The present study 
      failed to reveal significant differences between enzyme activities in biopsies 
      from patients in Stage I, II, and III; no correlation could be established 
      between enzyme activity and prognosis.
FAU - Pedersen, S N
AU  - Pedersen SN
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 9005-79-2 (Glycogen)
RN  - EC 1.1.- (Alcohol Oxidoreductases)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 1.1.1.49 (Glucosephosphate Dehydrogenase)
RN  - EC 2.7.- (Phosphotransferases)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 2.7.1.11 (Phosphofructokinase-1)
RN  - EC 2.7.1.40 (Pyruvate Kinase)
SB  - IM
MH  - Alcohol Oxidoreductases/*metabolism
MH  - Biopsy
MH  - Carcinoma in Situ/enzymology
MH  - Cervix Uteri/*enzymology
MH  - Female
MH  - Glucosephosphate Dehydrogenase/metabolism
MH  - Glycogen/*metabolism
MH  - Hexokinase/metabolism
MH  - Humans
MH  - L-Lactate Dehydrogenase/metabolism
MH  - Phosphofructokinase-1/metabolism
MH  - Phosphotransferases/*metabolism
MH  - Precancerous Conditions/*enzymology
MH  - Prognosis
MH  - Pyruvate Kinase/metabolism
MH  - Uterine Cervical Neoplasms/*enzymology
EDAT- 1975/02/01 00:00
MHDA- 1975/02/01 00:01
CRDT- 1975/02/01 00:00
PHST- 1975/02/01 00:00 [pubmed]
PHST- 1975/02/01 00:01 [medline]
PHST- 1975/02/01 00:00 [entrez]
AID - 10.1002/1097-0142(197502)35:2<469::aid-cncr2820350226>3.0.co;2-r [doi]
PST - ppublish
SO  - Cancer. 1975 Feb;35(2):469-74. doi: 
      10.1002/1097-0142(197502)35:2<469::aid-cncr2820350226>3.0.co;2-r.