PMID- 16313481
OWN - NLM
STAT- MEDLINE
DCOM- 20051227
LR  - 20181203
IS  - 0954-6820 (Print)
IS  - 0954-6820 (Linking)
VI  - 258
IP  - 6
DP  - 2005 Dec
TI  - HHV-6-related acute liver failure in two immunocompetent adults: favourable 
      outcome after liver transplantation and/or ganciclovir therapy.
PG  - 573-8
AB  - Fulminant hepatitis of unknown origin remain a significant cause of mortality, 
      for which liver transplantation is often considered as the only therapeutic 
      option. In retrospective studies, human herpesvirus 6 (HHV-6) infections have 
      been associated with such diseases, but the diagnosis of HHV-6 infection of the 
      liver is rarely established during the acute phase of liver failure. Using 
      real-time polymerase chain reaction (PCR), we diagnosed two cases of severe acute 
      liver failure (ALF) related to HHV-6 occurring in immunocompetent young adults. 
      Both cases had a favourable outcome, one after valganciclovir therapy, one after 
      liver transplantation associated with ganciclovir. Viral origin was evidenced in 
      each case by the detection of high amounts of HHV-6 DNA in liver tissue by the 
      PCR assay. The decrease of intrahepatic viral load after therapeutic intervention 
      was also monitored by quantitative PCR and paralleled in the two cases the 
      clinical improvement. Diagnosis of HHV-6 infection must be systematically evoked 
      in case of unexplained ALF, since it might lead to specific therapeutic 
      interventions, in addition of liver transplantation.
FAU - Cacheux, W
AU  - Cacheux W
AD  - Service d'Hepatologie, Hopital Saint-Antoine, Paris, France.
FAU - Carbonell, N
AU  - Carbonell N
FAU - Rosmorduc, O
AU  - Rosmorduc O
FAU - Wendum, D
AU  - Wendum D
FAU - Paye, F
AU  - Paye F
FAU - Poupon, R
AU  - Poupon R
FAU - Chazouilleres, O
AU  - Chazouilleres O
FAU - Gozlan, J
AU  - Gozlan J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - J Intern Med
JT  - Journal of internal medicine
JID - 8904841
RN  - 0 (Antiviral Agents)
RN  - GCU97FKN3R (Valganciclovir)
RN  - P9G3CKZ4P5 (Ganciclovir)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Antiviral Agents/*therapeutic use
MH  - Female
MH  - Ganciclovir/analogs & derivatives/*therapeutic use
MH  - *Herpesvirus 6, Human
MH  - Humans
MH  - Immunocompetence
MH  - Liver Failure, Acute/drug therapy/surgery/*virology
MH  - Liver Transplantation/*methods
MH  - Roseolovirus Infections/drug therapy/surgery/*therapy
MH  - Treatment Outcome
MH  - Valganciclovir
EDAT- 2005/11/30 09:00
MHDA- 2005/12/28 09:00
CRDT- 2005/11/30 09:00
PHST- 2005/11/30 09:00 [pubmed]
PHST- 2005/12/28 09:00 [medline]
PHST- 2005/11/30 09:00 [entrez]
AID - JIM1567 [pii]
AID - 10.1111/j.1365-2796.2005.01567.x [doi]
PST - ppublish
SO  - J Intern Med. 2005 Dec;258(6):573-8. doi: 10.1111/j.1365-2796.2005.01567.x.