PMID- 16313897
OWN - NLM
STAT- MEDLINE
DCOM- 20060309
LR  - 20071114
IS  - 0012-1606 (Print)
IS  - 0012-1606 (Linking)
VI  - 289
IP  - 1
DP  - 2006 Jan 1
TI  - The Drosophila Par domain protein I gene, Pdp1, is a regulator of larval growth, 
      mitosis and endoreplication.
PG  - 100-14
AB  - PDP1 is a basic leucine zipper (bZip) transcription factor that is expressed at 
      high levels in the muscle, epidermis, gut and fat body of the developing 
      Drosophila embryo. We have identified three mutant alleles of Pdp1, each having a 
      similar phenotype. Here, we describe in detail the Pdp1 mutant allele, 
      Pdp1(p205), which is null for both Pdp1 RNA and protein. Interestingly, 
      homozygous Pdp1(p205) embryos develop normally, hatch and become viable larvae. 
      Analyses of Pdp1 null mutant embryos reveal that the overall muscle pattern is 
      normal as is the patterning of the gut and fat body. Pdp1(p205) larvae also 
      appear to have normal muscle and gut function and respond to ecdysone. These 
      larvae, however, are severely growth delayed and arrested. Furthermore, although 
      Pdp1 null larvae live a normal life span, they do not form pupae and thus do not 
      give rise to eclosed flies. The stunted growth of Pdp1(p205) larvae is 
      accompanied by defects in mitosis and endoreplication similar to that associated 
      with nutritional deprivation. The cellular defects resulting from the Pdp1(p205) 
      mutation are not cell autonomous. Moreover, PDP1 expression is sensitive to 
      nutritional conditions, suggesting a link between nutrition, PDP1 isotype 
      expression and growth. These results indicate that Pdp1 has a critical role in 
      coordinating growth and DNA replication.
FAU - Reddy, Karen L
AU  - Reddy KL
AD  - Department of Biochemistry and Molecular Genetics M/C 669, University of Illinois 
      College of Medicine, Chicago, 60612, USA.
FAU - Rovani, Margritte K
AU  - Rovani MK
FAU - Wohlwill, Arthur
AU  - Wohlwill A
FAU - Katzen, Alisa
AU  - Katzen A
FAU - Storti, Robert V
AU  - Storti RV
LA  - eng
GR  - GM27611/GM/NIGMS NIH HHS/United States
GR  - GM68961/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20051128
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (Basic-Leucine Zipper Transcription Factors)
RN  - 0 (Drosophila Proteins)
RN  - 0 (PDP1 protein, Drosophila)
RN  - 3604-87-3 (Ecdysone)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Basic-Leucine Zipper Transcription Factors/genetics/*physiology
MH  - Cell Cycle/genetics
MH  - DNA Replication/*genetics
MH  - Drosophila Proteins/genetics/*physiology
MH  - Drosophila melanogaster/*genetics/*growth & development
MH  - Ecdysone/pharmacology
MH  - *Genes, Insect
MH  - Intestines/drug effects/physiology
MH  - Larva/genetics/growth & development
MH  - Mitosis/*genetics
MH  - Muscles/drug effects/physiology
MH  - Mutation
EDAT- 2005/11/30 09:00
MHDA- 2006/03/10 09:00
CRDT- 2005/11/30 09:00
PHST- 2005/01/26 00:00 [received]
PHST- 2005/09/30 00:00 [revised]
PHST- 2005/10/17 00:00 [accepted]
PHST- 2005/11/30 09:00 [pubmed]
PHST- 2006/03/10 09:00 [medline]
PHST- 2005/11/30 09:00 [entrez]
AID - S0012-1606(05)00744-X [pii]
AID - 10.1016/j.ydbio.2005.10.042 [doi]
PST - ppublish
SO  - Dev Biol. 2006 Jan 1;289(1):100-14. doi: 10.1016/j.ydbio.2005.10.042. Epub 2005 
      Nov 28.