PMID- 16317102
OWN - NLM
STAT- MEDLINE
DCOM- 20060508
LR  - 20220223
IS  - 0006-4971 (Print)
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 107
IP  - 7
DP  - 2006 Apr 1
TI  - SLAM/SLAM interactions inhibit CD40-induced production of inflammatory cytokines 
      in monocyte-derived dendritic cells.
PG  - 2821-9
AB  - Signaling lymphocyte activation molecule (SLAM, CD150, or SLAMF1) is a 
      self-ligand receptor on the surface of activated T- and B-lymphocytes, 
      macrophages, and dendritic cells (DCs). Here we examine the effect of SLAM/SLAM 
      interactions on CD40L-induced CD40 signaling pathways in human DCs. 
      CD40L-expressing L929 cells induced DCs to produce interleukin-6 (IL-6), tumor 
      necrosis factor-alpha (TNF-alpha), and IL-12, which was strongly inhibited by 
      coexpression of SLAM on the surface of the L929 cells. Similarly, transfection of 
      DCs with SLAM strongly reduced CD40L-induced IL-12 production. Furthermore, the 
      negative effect of SLAM/SLAM interactions on CD40L-induced DC activation was also 
      detected in the presence of lipopolysaccharide (LPS). LPS-induced IL-12 
      secretion, however, was not inhibited by SLAM engagement. CD40L-activated DCs 
      affected by exposure to SLAM/SLAM engagement were impaired in their ability to 
      induce differentiation of naive T lymphocytes into interferon-gamma 
      (IFN-gamma)-producing T-helper 1 (Th1) effector cells. These inhibitory effects 
      were not the result of a general unresponsiveness of DCs to CD40L, as SLAM/SLAM 
      interactions did not prevent CD40L-induced up-regulation of CD83, CD86, or human 
      leukocyte antigen (HLA)-DQ on the surface of DCs. Taken together, the results 
      indicate that SLAM/SLAM interactions inhibit CD40-induced signal transduction in 
      monocyte-derived dendritic cells, an effect that was not detectable in earlier 
      studies using anti-SLAM monoclonal antibodies.
FAU - Rethi, Bence
AU  - Rethi B
AD  - Institute of Immunology, University of Debrecen Medical and Health Science 
      Center, 98 Nagyerdei krt, H-4012 Debrecen, Hungary.
FAU - Gogolak, Peter
AU  - Gogolak P
FAU - Szatmari, Istvan
AU  - Szatmari I
FAU - Veres, Agota
AU  - Veres A
FAU - Erdos, Erika
AU  - Erdos E
FAU - Nagy, Laszlo
AU  - Nagy L
FAU - Rajnavolgyi, Eva
AU  - Rajnavolgyi E
FAU - Terhorst, Cox
AU  - Terhorst C
FAU - Lanyi, Arpad
AU  - Lanyi A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051129
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Antigens, CD)
RN  - 0 (CD40 Antigens)
RN  - 0 (Cytokines)
RN  - 0 (DNA Primers)
RN  - 0 (Glycoproteins)
RN  - 0 (Immunoglobulins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (SLAMF1 protein, human)
RN  - 0 (Slamf1 protein, mouse)
RN  - 147205-72-9 (CD40 Ligand)
RN  - 169535-43-7 (Signaling Lymphocytic Activation Molecule Family Member 1)
SB  - IM
MH  - Animals
MH  - Antigens, CD/genetics/immunology
MH  - CD40 Antigens/*immunology
MH  - CD40 Ligand/*immunology
MH  - Cytokines/*biosynthesis
MH  - DNA Primers
MH  - Dendritic Cells/*immunology
MH  - Glycoproteins/genetics/*immunology
MH  - Humans
MH  - Immunoglobulins/genetics/*immunology
MH  - Immunomagnetic Separation
MH  - Inflammation/immunology
MH  - L Cells
MH  - Mice
MH  - Monocytes/cytology/*immunology
MH  - Polymerase Chain Reaction
MH  - Receptors, Cell Surface
MH  - Signaling Lymphocytic Activation Molecule Family Member 1
MH  - Transfection
PMC - PMC1895370
EDAT- 2005/12/01 09:00
MHDA- 2006/05/09 09:00
PMCR- 2007/04/01
CRDT- 2005/12/01 09:00
PHST- 2005/12/01 09:00 [pubmed]
PHST- 2006/05/09 09:00 [medline]
PHST- 2005/12/01 09:00 [entrez]
PHST- 2007/04/01 00:00 [pmc-release]
AID - S0006-4971(20)65622-1 [pii]
AID - 2821 [pii]
AID - 10.1182/blood-2005-06-2265 [doi]
PST - ppublish
SO  - Blood. 2006 Apr 1;107(7):2821-9. doi: 10.1182/blood-2005-06-2265. Epub 2005 Nov 
      29.