PMID- 16317825
OWN - HSR
STAT- MEDLINE
DCOM- 20051212
LR  - 20161124
IS  - 1488-6316 (Print)
IS  - 1488-6316 (Linking)
IP  - 72
DP  - 2005 Sep
TI  - Sativex for the management of multiple sclerosis symptoms.
PG  - 1-4
AB  - Sativex (R) is a cannabis-based pharmaceutical product containing delta 
      9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in a 1:1 ratio, delivered in 
      an oromucosal (mouth) spray. It has been approved as adjunctive treatment for 
      neuropathic pain in patients with multiple sclerosis (MS). It is being 
      investigated for the management of other MS symptoms, such as spasticity. THC:CBD 
      spray is regulated as a narcotic. Five randomized controlled trials (RCTs) 
      compared the benefits and harms of THC:CBD spray with placebo. A total of 368 
      patients with various neurological conditions (including MS) were recruited. In 
      some trials, THC:CBD spray significantly reduced neuropathic pain, spasticity, 
      muscle spasms and sleep disturbances. The most common adverse events (AEs) 
      reported in trials were dizziness, sleepiness, fatigue, feeling of intoxication 
      and a bad taste. Long-term safety and the potential for dependence, abuse, misuse 
      and diversion are unknown.
FAU - Perras C
AU  - Perras C
LA  - eng
PT  - Journal Article
PL  - Canada
TA  - Issues Emerg Health Technol
JT  - Issues in emerging health technologies
JID - 100886782
RN  - 0 (Aerosols)
RN  - 0 (Analgesics)
RN  - 0 (Plant Extracts)
RN  - 19GBJ60SN5 (Cannabidiol)
RN  - 7J8897W37S (Dronabinol)
MH  - Administration, Oral
MH  - Administration, Sublingual
MH  - Aerosols
MH  - Analgesics/pharmacology/therapeutic use
MH  - Canada
MH  - Cannabidiol/administration & dosage/adverse effects/*therapeutic use
MH  - Dronabinol/administration & dosage/adverse effects/*therapeutic use
MH  - Drug Approval
MH  - Humans
MH  - Multiple Sclerosis/complications/*drug therapy
MH  - Muscle Spasticity/drug therapy/etiology
MH  - Pain/drug therapy/etiology
MH  - Phytotherapy
MH  - Plant Extracts/pharmacology/*therapeutic use
MH  - Randomized Controlled Trials as Topic
MH  - Sleep Wake Disorders/drug therapy/etiology
MH  - Tremor/drug therapy/etiology
MH  - United Kingdom
EDAT- 2005/12/02 09:00
MHDA- 2005/12/15 09:00
CRDT- 2005/12/02 09:00
PHST- 2005/12/02 09:00 [pubmed]
PHST- 2005/12/15 09:00 [medline]
PHST- 2005/12/02 09:00 [entrez]
PST - ppublish
SO  - Issues Emerg Health Technol. 2005 Sep;(72):1-4.