PMID- 16318875
OWN - NLM
STAT- MEDLINE
DCOM- 20060418
LR  - 20220316
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 141
IP  - 1
DP  - 2006 Jan 30
TI  - Prediction of medication noncompliance in outpatients with schizophrenia: 2-year 
      follow-up study.
PG  - 61-9
AB  - Neuroleptic noncompliance is a major reason for relapse in outpatients with 
      schizophrenia. In a 2-year follow-up study, we used the Japanese version of the 
      Rating of Medication Influences Scale (ROMI-J) to investigate the reasons for 
      compliance and noncompliance in outpatients with schizophrenia. Ninety 
      outpatients who were confirmed by interview to have had good compliance for more 
      than 3 months completed the initial interview, which included the Clinical Global 
      Impressions Scale (CGI), the Brief Psychiatric Rating Scale (BPRS), the Global 
      Assessment of Functioning Scale (GAF), the UKU Side Effect Rating Scale, and the 
      ROMI-J. All the outpatients were followed up for 2 years. At the initial 
      interview, the most frequent reason for compliance was "relapse prevention," 
      while the most frequent reason for noncompliance was "distressed by side 
      effects." Fifteen outpatients who proved to be noncompliant in the follow-up 
      period had higher baseline BPRS "agitation" scores and ROMI-J "no perceived daily 
      benefit" ratings than compliant patients. Sixty-four outpatients who maintained 
      compliance during the follow-up had higher baseline ROMI-J ratings of 
      "fulfillment of life goals" than their noncompliant counterparts. It is important 
      to understand the attitudes of patients with schizophrenia toward drug therapy in 
      order to predict better compliance and provide psychoeducation designed to 
      forestall relapses.
FAU - Yamada, Kazuo
AU  - Yamada K
AD  - Department of Psychiatry, Tokyo Women's Medical University, Medical Center East, 
      2-1-10 Nishi-ogu, Arakawa-ku, Tokyo 116-8567, Japan. yamadaps@dnh.twmu.ac.jp
FAU - Watanabe, Koichiro
AU  - Watanabe K
FAU - Nemoto, Naoyuki
AU  - Nemoto N
FAU - Fujita, Hidechika
AU  - Fujita H
FAU - Chikaraishi, Chikayo
AU  - Chikaraishi C
FAU - Yamauchi, Keita
AU  - Yamauchi K
FAU - Yagi, Gohei
AU  - Yagi G
FAU - Asai, Masahiro
AU  - Asai M
FAU - Kanba, Shigenobu
AU  - Kanba S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20051128
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Ambulatory Care
MH  - Antipsychotic Agents/*therapeutic use
MH  - Attitude to Health
MH  - Brief Psychiatric Rating Scale
MH  - Female
MH  - Follow-Up Studies
MH  - Health Behavior
MH  - Humans
MH  - Interview, Psychological
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Schizophrenia/diagnosis/drug therapy/*therapy
MH  - Surveys and Questionnaires
MH  - Treatment Refusal/*statistics & numerical data
EDAT- 2005/12/02 09:00
MHDA- 2006/04/19 09:00
CRDT- 2005/12/02 09:00
PHST- 2003/10/10 00:00 [received]
PHST- 2004/07/19 00:00 [revised]
PHST- 2004/07/20 00:00 [accepted]
PHST- 2005/12/02 09:00 [pubmed]
PHST- 2006/04/19 09:00 [medline]
PHST- 2005/12/02 09:00 [entrez]
AID - S0165-1781(05)00211-8 [pii]
AID - 10.1016/j.psychres.2004.07.014 [doi]
PST - ppublish
SO  - Psychiatry Res. 2006 Jan 30;141(1):61-9. doi: 10.1016/j.psychres.2004.07.014. 
      Epub 2005 Nov 28.