PMID- 16320975
OWN - NLM
STAT- MEDLINE
DCOM- 20051216
LR  - 20131121
IS  - 0914-5087 (Print)
IS  - 0914-5087 (Linking)
VI  - 46
IP  - 5
DP  - 2005 Nov
TI  - [Feasibility of cardiopulmonary rehabilitation in patients with idiopathic 
      pulmonary arterial hypertension treated with intravenous prostacyclin infusion 
      therapy].
PG  - 183-93
AB  - OBJECTIVES: To evaluate cardiopulmonary rehabilitation in patients with 
      idiopathic pulmonary arterial hypertension who had severe heart failure. METHODS: 
      The subjects comprised 11 men and 13 women aged 5 to 37 years old with idiopathic 
      pulmonary arterial hypertension, who received cardiopulmonary rehabilitation 
      following the start of continuous intravenous prostacyclin administration between 
      January 1999 and September 2003. Fifteen patients were categorized in New York 
      Heart Association (NYHA) functional class-III and 9 were class-IV on admission. 
      Patients received cardiopulmonary rehabilitation consisting of breathing 
      exercise, training of upper extremity muscles, gait training, bicycle ergometer 
      training, and treadmill walking for 30 to 60 min per day, 5 days a week. 
      Cardiothoracic ratio, NYHA class, heart rate, pulse oximeter saturation, plasma 
      levels of human atrial natriuretic peptide and brain natriuretic peptide, 
      tricuspid regurgitation, and right ventricular myocardial index (RV Tei index) 
      were evaluated by echocardiography, lower extremity muscle strength, ambulation 
      ability, Barthel index, and 6-minute walking distance at the beginning and end of 
      cardiopulmonary rehabilitation. RESULTS: The average period of cardiopulmonary 
      rehabilitation was 6.7 weeks. There was no deterioration in cardiothoracic ratio, 
      human atrial natriuretic peptide, brain natriuretic peptide levels, tricuspid 
      regurgitation, RV Tei index and pulse oximeter saturation. The results also 
      showed decreased heart rate at rest (p = 0.007), and improved NYHA class (p = 
      0.010), lower extremity strength (p < 0.001), ambulation ability (p < 0.001), 
      Barthel index (p < 0.001), and 6-minute walking distance (p = 0.001). 
      CONCLUSIONS: Cardiopulmonary rehabilitation is safe and effective for idiopathic 
      pulmonary arterial hypertension patients in NYHA class-III and IV during 
      intravenous prostacyclin infusion without deterioration of cardiac functions, 
      despite the conventional contraindication.
FAU - Uchi, Masayuki
AU  - Uchi M
AD  - Department of Physical Medicine and Rehabilitation, School of Medicine, Faculty 
      of Medicine, Toho University, Tokyo. masayuki@med.toho-u.ac.jp
FAU - Saji, Tsutomu
AU  - Saji T
FAU - Harada, Takashi
AU  - Harada T
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
RN  - 0 (Antihypertensive Agents)
RN  - DCR9Z582X0 (Epoprostenol)
SB  - IM
MH  - Activities of Daily Living
MH  - Adolescent
MH  - Adult
MH  - Antihypertensive Agents/*administration & dosage
MH  - Child
MH  - Child, Preschool
MH  - Combined Modality Therapy
MH  - Epoprostenol/*administration & dosage
MH  - Exercise Tolerance
MH  - Female
MH  - Heart Failure/complications
MH  - Humans
MH  - Hypertension, Pulmonary/complications/*drug therapy/*rehabilitation
MH  - Infusions, Intravenous
MH  - Male
EDAT- 2005/12/03 09:00
MHDA- 2005/12/17 09:00
CRDT- 2005/12/03 09:00
PHST- 2005/12/03 09:00 [pubmed]
PHST- 2005/12/17 09:00 [medline]
PHST- 2005/12/03 09:00 [entrez]
PST - ppublish
SO  - J Cardiol. 2005 Nov;46(5):183-93.