PMID- 16321508
OWN - NLM
STAT- MEDLINE
DCOM- 20060609
LR  - 20191210
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 81
IP  - 2-3
DP  - 2006 Jan 31
TI  - Spatial working memory deficits in adolescents at clinical high risk for 
      schizophrenia.
PG  - 211-5
AB  - Identifying endophenotypic markers is crucial to schizophrenia research for 
      finding appropriate preventive strategies. Working memory (WM) deficit has been 
      suggested as a marker for schizophrenia but its presence in adolescents at high 
      risk is understudied. We piloted a test of spatial WM function in adolescents at 
      clinical high risk (CHR) for schizophrenia and in age- and IQ-matched low-risk 
      control subjects. CHR adolescents showed deficits in spatial WM compared with 
      controls but showed intact performance on a non-WM-demanding spatial control 
      task. Although based on a small pilot study, the results strongly suggest that WM 
      deficit may be a risk factor for psychosis.
FAU - Smith, Christopher W
AU  - Smith CW
AD  - Recognition and Prevention (RAP) Program, Department of Psychiatry Research, The 
      Zucker Hillside Hospital, North Shore-Long Island Jewish Health System (NSLIJHS) 
      Glen Oaks, NY 11042, USA. csmith@lij.edu
FAU - Park, Sohee
AU  - Park S
FAU - Cornblatt, Barbara
AU  - Cornblatt B
LA  - eng
GR  - MH-50203/MH/NIMH NIH HHS/United States
GR  - MH-58406/MH/NIMH NIH HHS/United States
GR  - MH-61523/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adolescent
MH  - Attention
MH  - Female
MH  - Humans
MH  - Male
MH  - *Memory, Short-Term
MH  - *Orientation
MH  - *Pattern Recognition, Visual
MH  - Phenotype
MH  - Pilot Projects
MH  - Psychomotor Performance
MH  - Reaction Time
MH  - Retention, Psychology
MH  - Risk
MH  - Schizophrenia/diagnosis/*genetics
MH  - *Schizophrenic Psychology
MH  - Schizotypal Personality Disorder/*diagnosis/*psychology
EDAT- 2005/12/03 09:00
MHDA- 2006/06/10 09:00
CRDT- 2005/12/03 09:00
PHST- 2005/08/24 00:00 [received]
PHST- 2005/09/21 00:00 [revised]
PHST- 2005/09/23 00:00 [accepted]
PHST- 2005/12/03 09:00 [pubmed]
PHST- 2006/06/10 09:00 [medline]
PHST- 2005/12/03 09:00 [entrez]
AID - S0920-9964(05)00463-9 [pii]
AID - 10.1016/j.schres.2005.09.019 [doi]
PST - ppublish
SO  - Schizophr Res. 2006 Jan 31;81(2-3):211-5. doi: 10.1016/j.schres.2005.09.019.